Gene

MITF

melanocyte inducing transcription factor

Explore in graph →CI-GENE-00014620HGNC:7105 ENSG00000187098 NCBI 4286 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MITF Amplification1
Dabrafenib + VemurafenibSubstitutes	Melanoma	Predictive	C	Supports Resistance	4	submitted	EID7668 In a retrospective study, resistance mechanisms to BRAF inhibitor such as vemurafenib or dabrafenib in patients with BRAF V600 mutated melanoma were evaluated. In one patient relapse-associated focal … (full text at CIViC) PMID 24265153 · Van Allen et al., 2014 · Open in CIViC	civic
MITF Overexpression1
PLX4720 + SelumetinibCombination	Melanoma	Predictive	D	Supports Resistance	3	submitted	EID1978 Preliminary analysis of biopsies from BRAF(V600E) melanoma patients revealed that phosphorylated (active) CREB was suppressed by RAF-MEK inhibition but restored in relapsing tumours. Expression of tra…

Cohorts

Alteration frequency by cohort (37)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved37 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	8

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Integrative clinical and molecular characterization of translocation renal cell carcinoma.
· Cell Rep · 2022 · PMID 34986355 · validated civic_curation pubmed

MITF Fusion1
(diagnostic)	Renal Cell Carcinoma with MiT Translocations	Diagnostic	C	Supports Positive	1	accepted	EID11702 Bakouny, et al. (2022) performed a comprehensive study of the molecular and clinical features of 90 translocation renal cell carcinomas (tRCCs), defined as subtype of kidney cancer driven by MiT/TFE g… (full text at CIViC) PMID 34986355 · Bakouny et al., 2022 · Open in CIViC	civic

MITF Fusion1

(diagnostic)

Renal Cell Carcinoma with MiT Translocations

Diagnostic

Supports Positive

accepted

EID11702

Bakouny, et al. (2022) performed a comprehensive study of the molecular and clinical features of 90 translocation renal cell carcinomas (tRCCs), defined as subtype of kidney cancer driven by MiT/TFE g… (full text at CIViC)

PMID 34986355 · Bakouny et al., 2022 · Open in CIViC

civic