MEF2B mutation

CI-VAR-00005016Explore in graph →CIViC 4784

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Diffuse Large B-Cell Lymphoma1
MEF2B mutation	(oncogenic)	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11919 Multiple studies have demonstrated an enrichment for somatic missense mutations in MEF2B including multiple hot spots. PMID 21796119 · Morin et al., 2011 · Open in CIViC	civic
Mantle Cell Lymphoma1
MEF2B mutation	(oncogenic)	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11872 [the study] identified 25 significantly mutated genes, including known drivers such as ataxia-telangectasia mutated (ATM), cyclin D1 (CCND1), and the tumor suppressor TP53; mutated genes encoding the … (full text at CIViC) PMID 24145436 · Beà et al., 2013 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.