Gene

LEPR

leptin receptor

Explore in graph →CI-GENE-00007750HGNC:6554 ENSG00000116678 NCBI 3953 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
LEPR UNDEREXPRESSION1
(prognostic)	Meningioma	Prognostic	B	Supports Poor Outcome	2	accepted	EID1054 144 cases (discovery set: N=62 discovery; Independent validation set: N = 82) of meningiomas were analyzed for transcriptional features defining aggressive clinical course (recurrent, malignantly prog… (full text at CIViC) PMID 26894859 · Schmidt et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (5)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved5 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cutaneous Squamous Cell Carcinoma (UOW, Front Oncol 2022) cscc_ranson_2022	Skin Squamous Cell Carcinoma	Ssm	17

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.
· Oncotarget · 2016 · PMID 26894859 · validated civic_curation pubmed