Gene

KDM5C

lysine demethylase 5C

Explore in graph →CI-GENE-00006808HGNC:11114 ENSG00000126012 NCBI 8242 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
KDM5C Loss-of-function + PIK3CA E545K + PIK3CA H1047R + PTEN LossPIK3CA PTEN KDM5C1
Capivasertib	Estrogen Receptor-positive Breast CancerUNRESOLVED	Predictive	D	Supports Sensitivity Response	3	submitted	EID12936 In ER+ breast cancer cell line models with PI3K-AKT pathway alterations (MCF7 with PIK3CA E545K, T47D with PIK3CA H1047R, CAMA‑1 with PTEN deletion), CRISPR knockout screens identified KDM5C as a modi… (full text at CIViC) PMID 41983950 · Cutano et al., 2026 · Open in CIViC	civic
KDM5C Mutation1
Everolimus + SunitinibSequential	Renal Cell CarcinomaCURATED_BROADER

Cohorts

Alteration frequency by cohort (133)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved133 cohort rows (showing 33, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial Cancer (MSK, Cancer Discovery 2023) ucec_ancestry_cds_msk_2023	Endometrial Carcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.