KDM5C Loss-of-function

CI-VAR-00002547Explore in graph →CIViC 5453

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Estrogen Receptor-positive Breast Cancer1unmapped disease
KDM5C Loss-of-function AND ( PIK3CA E545K OR PIK3CA H1047R OR PTEN Loss )	Capivasertib	Predictive	D	Supports Sensitivity Response	3	submitted	EID12936 In ER+ breast cancer cell line models with PI3K-AKT pathway alterations (MCF7 with PIK3CA E545K, T47D with PIK3CA H1047R, CAMA‑1 with PTEN deletion), CRISPR knockout screens identified KDM5C as a modi… (full text at CIViC) PMID 41983950 · Cutano et al., 2026 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.