Publication
Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerColon Adenocarcinomacivic_curation1.00
- cancerColorectal Adenocarcinomacivic_curation1.00
- drugIrbesartancivic_curation1.00
- geneFOScivic_curation1.00
- geneJUNcivic_curation1.00
- variantFOS Overexpressioncivic_curation1.00
- variantJUN Overexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27022066
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FOS Overexpression1 | ||||||||
| Irbesartan | Colon Adenocarcinoma | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID1634A 67-year-old female presents with recurrent metastatic colonic adenocarcinoma. Immunohistochemical and genetic workup showed overexpression of c-JUN and FOS, which presumably signals through the RAA… (full text at CIViC) PMID 27022066 · Jones et al., 2016 · Open in CIViC | civic |
| JUN Overexpression1 | ||||||||
| Irbesartan | Colorectal Adenocarcinoma | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID1633A 67-year-old female presents with recurrent metastatic colonic adenocarcinoma. Immunohistochemical and genetic workup showed overexpression of c-JUN and FOS, which presumably signals through the RAA… (full text at CIViC) PMID 27022066 · Jones et al., 2016 · Open in CIViC | civic |