Gene

H3C4

H3 clustered histone 4

Explore in graph →CI-GENE-00004010HGNC:4767 ENSG00000197409 NCBI 8351 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
H3C4 K28M1
(oncogenic)	Posterior Fossa Ependymoma, Group A (PFA)ALIAS	Oncogenic	C	Supports Oncogenicity	2	accepted	EID13074 Mariet et al. identified a somatic H3C4 (HIST1H3D) p.Lys28Met (K27M) mutation in a posterior fossa group A ependymoma (EPN_PFA) from an 8-year-old male. The tumor showed H3 K27M immunoreactivity, loss… (full text at CIViC) PMID 36104744 · Mariet et al., 2022 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (17)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved17 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Metaplastic Breast Cancer (MSK,NPJ Breast Cancer 2021) mbc_msk_2021	Breast Metaplastic Carcinoma	Ssm	1

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysis.
· Acta Neuropathol Commun · 2022 · PMID 36104744 · validated civic_curation pubmed