Publication
Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysis.
Authors not recorded
Acta Neuropathol Commun2022PMID 36104744PMC9476256stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260926-000001
Abstract
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerPosterior Fossa Ependymoma, Group A (PFA)civic_curation1.00
- geneH3C4civic_curation1.00
- variantH3C4 K28Mcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 36104744
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| H3C4 K28M1 | ||||||||
| (oncogenic) | Posterior Fossa Ependymoma, Group A (PFA)ALIAS | Oncogenic | C | Supports Oncogenicity | 2 | accepted | EID13074Mariet et al. identified a somatic H3C4 (HIST1H3D) p.Lys28Met (K27M) mutation in a posterior fossa group A ependymoma (EPN_PFA) from an 8-year-old male. The tumor showed H3 K27M immunoreactivity, loss… (full text at CIViC) PMID 36104744 · Mariet et al., 2022 · Open in CIViC | civic |