Gene

H3C2

H3 clustered histone 2

Explore in graph →CI-GENE-00004008HGNC:4776 ENSG00000286522 NCBI 8358 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (8)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–8 of 8 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
H3C2 K27M8
(diagnostic)	Diffuse Midline Glioma, H3 K27-Altered	Diagnostic	B	Supports Positive	3	accepted	EID9546 Whole-genome sequencing (WGS) was performed on the diffuse intrinsic pontine gliomas (DIPGs) and matched germline DNA of 7 pediatric patients. Targeted sequencing was performed on an additional 43 DIP…

Cohorts

Alteration frequency by cohort (41)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved41 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Diffuse Large B-Cell Lymphoma (Broad, PNAS 2012) dlbc_broad_2012	Diffuse Large B-Cell Lymphoma Unclassifiable	Ssm

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
· Nat Genet · 2012 · PMID 22286216 · validated civic_curation pubmed
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.
· Science · 2013 · PMID 23539183 · validated civic_curation pubmed