H3-3B — gene · CancerIndex

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
H3-3B K28I1
(oncogenic)	Diffuse Midline Glioma, H3 K27-Altered	Oncogenic	C	Supports Oncogenicity	2	submitted	EID13073 Two adult patients with diffuse midline glioma (DMG) harboring a somatic H3F3B K27I mutation were reported. Next-generation sequencing on postoperative tissue was performed using a 539-gene panel (Si… (full text at CIViC) Open in CIViC	civic
H3-3B K36M1
(diagnostic)	Chondroblastoma	Diagnostic	B	Supports Positive	4	accepted	EID6463 Behjati et al identified K36M mutations in a set of 77 chondroblastomas. Chondroblastoma is a typically a pediatric or early adult cancer. Of the 77, 5 had K36M mutations in H3F3A, 68 had K36M in H3F3… (full text at CIViC) PMID 24162739 · Behjati et al., 2013 · Open in CIViC

Cohorts

Alteration frequency by cohort (11)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved11 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	8

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.
· Nat Genet · 2013 · PMID 24162739 · validated civic_curation pubmed