Publication
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerChondroblastomacivic_curation1.00
- cancerGiant Cell Tumor of Bonecivic_curation1.00
- geneH3-3Acivic_curation1.00
- geneH3-3Bcivic_curation1.00
- variantH3-3A G35Wcivic_curation1.00
- variantH3-3B K36Mcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24162739
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| H3-3B K36M1 | ||||||||
| (diagnostic) | Chondroblastoma | Diagnostic | B | Supports Positive | 4 | accepted | EID6463Behjati et al identified K36M mutations in a set of 77 chondroblastomas. Chondroblastoma is a typically a pediatric or early adult cancer. Of the 77, 5 had K36M mutations in H3F3A, 68 had K36M in H3F3… (full text at CIViC) PMID 24162739 · Behjati et al., 2013 · Open in CIViC | civic |
| H3-3A G35W1 | ||||||||
| (diagnostic) | Giant Cell Tumor of BoneALIAS | Diagnostic | B | Supports Positive | 4 | accepted | EID6469In this study, the authors analyzed 53 cases of giant cell tumour of bone using capillary sequencing and massively parallel sequencing. They identified histone 3.3 mutations in 49/53 cases (92%). All … (full text at CIViC) PMID 24162739 · Behjati et al., 2013 · Open in CIViC | civic |