Gene
GSTP1
glutathione S-transferase pi 1
Explore in graph →CI-GENE-00003730HGNC:4638 ENSG00000084207 NCBI 2950 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (2)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19922504
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GSTP1 I105V1 | ||||||||
| FOLFOX Regimen | Malignant Colorectal NeoplasmCURATED_BROADER | Predictive | B | Supports Sensitivity Response | 4 | accepted | EID670Patients with the GSTP1 I105V variant had greater response to FOLFOX-4 treatment, longer progression-free survival, and longer overall survival. 166 Chinese patients with metastatic colorectal carcino… (full text at CIViC) PMID 19922504 · Chen et al., 2010 · Open in CIViC | civic |
| GSTP1 Underexpression1 | ||||||||
| Carboplatin + Cisplatin + PaclitaxelSubstitutes | Ovarian Carcinoma | Predictive | D | Supports Sensitivity Response | 4 | accepted | ||
Cohorts
Alteration frequency by cohort (2)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 35121644
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Metastatic Triple Negative Breast Cancer (UNC Phase II Trial, J Immunother Cancer 2022) - iAtlas Harmonized brca_iatlas_anders_2022 | Invasive Breast Carcinoma | Ssm |
Literature
Linked publications (2)
25 per page, newest first.
pubmedProvenance
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)