Publication
Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines.
Authors not recorded
Br J Cancer2014PMID 25010864PMC4453841stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerOvarian Carcinomacivic_curation1.00
- drugCarboplatincivic_curation1.00
- drugCisplatincivic_curation1.00
- drugPaclitaxelcivic_curation1.00
- geneGSTP1civic_curation1.00
- variantGSTP1 Underexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25010864
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GSTP1 Underexpression1 | ||||||||
| Carboplatin + Cisplatin + PaclitaxelSubstitutes | Ovarian Carcinoma | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID660Stable GSTP1 knockdown in ovarian carcinoma A2780 cell lines showed increased sensitivity to platinum-based chemotherapy drugs carboplatin, cisplatinum, carboplatin, and paclitaxel. For each drug, 3 b… (full text at CIViC) PMID 25010864 · Sawers et al., 2014 · Open in CIViC | civic |