Gene
GLI1
GLI family zinc finger 1
Explore in graph →CI-GENE-00003079HGNC:4317 ENSG00000111087 NCBI 2735 Cancer geneApproved
Curated evidence
Clinical evidence (5)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 15555571
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GLI1 Fusion1 | ||||||||
| (diagnostic) | GLI1-Altered Soft Tissue TumorALIAS | Diagnostic | B | Supports Positive | 3 | accepted | EID1844Pericytoma with t(7;12) is a soft tissue tumor characterized by fusion of the ACTB and GLI genes through the translocation t(7;12)(p22;q13). In this study the genomic breakpoints of 5 cases were chara… (full text at CIViC) PMID 15555571 · Dahlén et al., 2004 · Open in CIViC | civic |
| GLI1 Fusion4 | ||||||||
| (diagnostic) | Gastroblastoma | Diagnostic | C | Supports Positive | 4 | accepted | EID12080This study identified a recurrent MALAT1::GLI1 fusion in 4 of 4 (100%) gastroblastomas from patients ranging in age from 9 to 56 years old. Initially, the fusion was identified using transcriptome seq… (full text at CIViC) | |
Cohorts
Alteration frequency by cohort (111)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Adrenocortical Carcinoma TCGA-ACC | Adrenal Cortical CarcinomaALIAS |
Literature
Linked publications (5)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)