GLI1-Altered Soft Tissue Tumor — Variants & evidence

GLI1-Altered Soft Tissue Tumor — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items (4 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
GLI1 Fusion1
(diagnostic)	GLI1-Altered Soft Tissue TumorALIAS	Diagnostic	B	Supports Positive	3	accepted	EID1844 Pericytoma with t(7;12) is a soft tissue tumor characterized by fusion of the ACTB and GLI genes through the translocation t(7;12)(p22;q13). In this study the genomic breakpoints of 5 cases were chara… (full text at CIViC) PMID 15555571 · Dahlén et al., 2004 · Open in CIViC	civic
GLI1 Fusion4
(diagnostic)	Gastroblastoma	Diagnostic	C	Supports Positive	4	accepted	EID12080 This study identified a recurrent MALAT1::GLI1 fusion in 4 of 4 (100%) gastroblastomas from patients ranging in age from 9 to 56 years old. Initially, the fusion was identified using transcriptome seq… (full text at CIViC) PMID 37165307 · Hamada et al., 2023 · Open in CIViC	civic
〃	Gastroblastoma	Diagnostic	C	Supports Positive	4	accepted	EID12753 In this 2017 study the authors included four cases of gastroblastoma with control cases of histologic mimics. Gastroblastoma patients were aged 9, 27, 28 and 56 years. RNASeq identified a MALAT1::GLI1… (full text at CIViC) PMID 28731043 · Graham et al., 2017 · Open in CIViC	civic
〃	Gastroblastoma	Diagnostic	C	Supports Positive	2	accepted

Data updated 14 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.