GATA3

GATA binding protein 3

Explore in graph →CI-GENE-00002800HGNC:4172 ENSG00000107485 NCBI 2625 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
GATA3 Mutation + GNAS Mutation + KRAS G12RKRAS GATA3 GNAS1
Cobimetinib	Histiocytosis-Lymphadenopathy Plus SyndromeUNRESOLVED	Predictive	C	Supports Sensitivity Response	2	submitted	EID11330 This case study is on a 60-year-old man with a 7-year history of fatigue that was noted to have a palpable abdominal mass while being seen for gastroesophageal reflux disease. A CT scan of the abdomen… (full text at CIViC) PMID 29236635 · Jacobsen et al., 2017 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (113)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved113 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
MYC Family Amplifications in MSK-IMPACT Solid Tumors (MSK, 2026) mycf_msk_2026	unmapped	Ssm	119	3,442	3.5%	25

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.