Gene

FN1

fibronectin 1

Explore in graph →CI-GENE-00002082HGNC:3778 ENSG00000115414 NCBI 2335 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FN1 EDB3
Daromun	Melanoma	Predictive	B	Supports Sensitivity Response	4	submitted	EID9624 In a clinical trial including 20 patients and 105 lesions, intralesional administration of L19IL2/L19TNF shows 30.5% CR, 17.1% PR, 25.7% SD, 5.7% PD and 21% non-CR. PMID 25971540 · Danielli et al., 2015 · Open in CIViC	civic
L19IL2	Melanoma	Predictive	B	Supports Sensitivity Response	4	submitted	EID9626 In a clinical study including 25 patients, patients treated with L19IL2 show 44.4% irCR, 9.5% irPR, 36.5% ires ans 9.5% irPD. PMID 24906352 · Weide et al., 2014 · Open in CIViC	civic
Dacarbazine + L19IL2Combination

Cohorts

Alteration frequency by cohort (37)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved37 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Small-Cell Lung Cancer (Multi-Institute, Cancer Cell 2017) sclc_cancercell_gardner_2017	Lung Small Cell Carcinoma	Ssm	16

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.