Gene

ERCC3

ERCC excision repair 3, TFIIH core complex helicase subunit

Explore in graph →CI-GENE-00044917HGNC:3435 ENSG00000163161 NCBI 2071 CIViC Approved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ERCC2 Mutation + ERCC3 Mutation + ERCC4 Mutation + ERCC5 MutationERCC2 ERCC3 ERCC4 ERCC53
(prognostic)	Malignant NeoplasmALIAS	Prognostic	B	Supports Better Outcome	2	submitted	EID12645 In two independent retrospective pan-cancer cohorts without ICI treatment (TCGA cohort 1 n = 3292; MSK-MET cohort 2 n = 25,659), tumors harboring ERCC2/ERCC3/ERCC4/ERCC5 mutations showed improved OS v… (full text at CIViC) PMID 37626083 · Chen et al., 2023 · Open in CIViC	civic
Immune Checkpoint Inhibitor	Melanoma	Predictive	B	Supports Sensitivity Response	3	submitted

Cohorts

Alteration frequency by cohort (41)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved41 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024	Endometrial Carcinoma	Ssm	9	69

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.