Gene

ERCC1

ERCC excision repair 1, endonuclease non-catalytic subunit

Explore in graph →CI-GENE-00044915HGNC:3433 ENSG00000012061 NCBI 2067 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (11)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–11 of 11 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ERCC1 Expression4
(prognostic)	Pleural Malignant MesotheliomaALIAS	Prognostic	B	Supports Poor Outcome	4	submitted

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Squamous Cell Carcinoma of the Vulva (CUK, Exp Mol Med 2018) vsc_cuk_2018	Vaginal Squamous Cell Carcinoma, Not Otherwise Specified	Ssm

Literature

Linked publications (3)

25 per page, newest first.

pubmedPublishedShowing 1–3 of 3 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

ERCC1 as a Prognostic and Predictive Biomarker for Urothelial Carcinoma of the Bladder following Radical Cystectomy.
· J Urol · 2015 · PMID 26162296 · validated civic_curation pubmed
Randomized phase III trial of gemcitabine-based chemotherapy with in situ RRM1 and ERCC1 protein levels for response prediction in non-small-cell lung cancer.
· J Clin Oncol · 2009 · PMID 19884554 · validated civic_curation pubmed
ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers.
· Gynecol Oncol · 2019 · PMID 30797591 · validated civic_curation pubmed

ERCC1 Underexpression6
(prognostic)	Lung Non-Small Cell CarcinomaCURATED_BROADER	Prognostic	B	Supports Better Outcome	3	submitted	EID8025 Expression level of ERCC1 was evaluated in 61 NSCLC samples with RT-qPCR. Kaplan-Meier analysis showed that low expression of ERCC1 was associated with longer median survival time (17.3 versus 10.9 mo… (full text at CIViC) PMID 16980606 · Ceppi et al., 2006 · Open in CIViC	civic
Cisplatin	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	submitted	EID6433 In this review article, the median survival of non-small cell lung cancer patients with low levels of ERCC1, treated with platinum-based therapies was significantly prolonged as compared to those with… (full text at CIViC) PMID 16807441 · Rosell et al., 2006 · Open in CIViC	civic
Carboplatin + GemcitabineCombination	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	accepted	EID10142 As part of a randomized phase III trial (USO-03012) in advanced NSCLC of gemcitabine vs. combination gemcitabine and carboplatin, protein expression levels for RRM1 (n=69) and ERCC1 (n=65) were evalua… (full text at CIViC) PMID 19884554 · Reynolds et al., 2009 · Open in CIViC	civic
Cisplatin + GemcitabineCombination	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	4	submitted	EID6431 The Median Survival Time (MST) in patients with low ERCC1 mRNA levels was significantly longer in the overall population than in patients with higher ERCC1 levels (17.3 versus 10.9 months, log-rank 8.… (full text at CIViC) PMID 16980606 · Ceppi et al., 2006 · Open in CIViC	civic
Platinum Compound	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	submitted	EID6430 In this study, the goal was to study the predictive effect of ERCC1 expression to platinum based chemotherapy in Chinese patients with Non-small cell lung cancer (NSCLC). Of the patients that did not … (full text at CIViC) PMID 19488864 · Wang et al., 2010 · Open in CIViC	civic
〃	Ovarian CarcinomaALIAS	Predictive	B	Supports Sensitivity Response	3	accepted	EID10146 Ovarian epithelial tumours (n=235) were used to create TMAs and IHC results were scored for ERCC1 (n=114 low, n=121 high). For platinum sensitive patients (n=250 in supplementary table, but not all ha… (full text at CIViC) PMID 30797591 · Mesquita et al., 2019 · Open in CIViC	civic