Variant · Expression
ERCC1 Underexpression
CI-VAR-00004422Explore in graph →CIViC 2409
Curated evidence
Evidence by cancer (6 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16980606
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Lung Non-Small Cell Carcinoma5 | ||||||||
| ERCC1 Underexpression | (prognostic) | Prognostic | B | Supports Better Outcome | 3 | submitted | EID8025Expression level of ERCC1 was evaluated in 61 NSCLC samples with RT-qPCR. Kaplan-Meier analysis showed that low expression of ERCC1 was associated with longer median survival time (17.3 versus 10.9 mo… (full text at CIViC) PMID 16980606 · Ceppi et al., 2006 · Open in CIViC | civic |
| ERCC1 Underexpression | Cisplatin | Predictive | B | Supports Sensitivity Response | 3 | submitted | EID6433In this review article, the median survival of non-small cell lung cancer patients with low levels of ERCC1, treated with platinum-based therapies was significantly prolonged as compared to those with… (full text at CIViC) PMID 16807441 · Rosell et al., 2006 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available