CYLD NM_001378743.1(CYLD):c.1112C>A (p.Ser371Ter)

CI-VAR-00049340Explore in graph →p.Ser371TerNM_001378743.1:c.1112C>AClinVar 267232 rs886040872

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
267232	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Familial cylindromatosis; Brooke-Spiegler syndrome; Trichoepithelioma, multiple familial, 1; Frontotemporal dementia and/or amyotrophic lateral sclerosis 8; Multiple monogenic benign skin tumours	germline	8	Dec 06, 2025	clinvar