CYLD NM_001378743.1(CYLD):c.2299A>T (p.Lys767Ter)

CI-VAR-00049342Explore in graph →p.Lys767TerNM_001378743.1:c.2299A>TClinVar 267249 rs886040888

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
267249	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Familial cylindromatosis; Brooke-Spiegler syndrome; Frontotemporal dementia and/or amyotrophic lateral sclerosis 8; SLC35A2-congenital disorder of glycosylation; CYLD-related disorder; Multiple monogenic benign skin tumours	germline	7	Feb 11, 2026	clinvar