CREB3L1 — gene · CancerIndex

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CREB3L1 Fusion3
(diagnostic)	Sclerosing Epithelioid Fibrosarcoma	Diagnostic	B	Supports Positive	3	accepted	EID12058 In this 2017 study, the authors utilized SNP arrays, expression profiling, transcriptome, and whole-exome sequencing to further characterize sclerosing epithelioid fibrosarcoma (SEF) and low-grade fi… (full text at CIViC) PMID 28939748 · Arbajian et al., 2017 · Open in CIViC	civic
〃	Sclerosing Epithelioid Fibrosarcoma	Diagnostic	C	Supports Positive	3	accepted	EID12057 In this 2014 study, the authors compared 10 primary sclerosing epithelioid fibrosarcomas (SEF), 4 cases of low-grade fibromyxoid sarcoma (LGFMS), and one primary hybrid SEF/LGFMS. Patients with SEF ra… (full text at CIViC) PMID 24441665 · Arbajian et al., 2014 · Open in CIViC

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Nerve Sheath Tumors (Johns Hopkins, 2024) nst_nfosi_ntap	Nerve Sheath Neoplasm	Ssm	6	80

Literature

Linked publications (3)

25 per page, newest first.

pubmedPublishedShowing 1–3 of 3 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets.
· Clin Cancer Res · 2017 · PMID 28939748 · validated civic_curation pubmed
Recurrent EWSR1-CREB3L1 gene fusions in sclerosing epithelioid fibrosarcoma.
· Am J Surg Pathol · 2014 · PMID 24441665 · validated civic_curation pubmed
A genetic dichotomy between pure sclerosing epithelioid fibrosarcoma (SEF) and hybrid SEF/low-grade fibromyxoid sarcoma: a pathologic and molecular study of 18 cases.
· Genes Chromosomes Cancer · 2015 · PMID 25231134 · validated civic_curation pubmed