Gene

CARD11

caspase recruitment domain family member 11

Explore in graph →CI-GENE-00032328HGNC:16393 ENSG00000198286 NCBI 84433 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CARD11 MUTATION3
(prognostic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Prognostic	D	Supports Poor Outcome	4	rejected	EID8344 The signalling adaptor CARD11 is required for constitutive NF-kappaB pathway activity and survival in ABC DLBCL. Roughly 10% of ABC DLBCLs have mutant CARD11 isoforms that activate NF-kappaB, but the … (full text at CIViC) PMID 20054396 · Davis et al., 2010 · Open in CIViC	civic
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11932 This study used a combination of RNA-seq, whole genome and targeted sequencing to identify recurrently mutated genes in follicular and diffuse large B-cell lymphoma. They reported 30 genes that had si… (full text at CIViC)

Cohorts

Alteration frequency by cohort (150)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved150 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Thoracic PDX (MSK, Provisional) lung_msk_pdx	unmapped	Ssm	13	315	4.1%	69

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.