Subtype
Childhood Medulloblastoma
CI-CAN-00002289Explore in graph →
Pediatric13 active trials2 evidence items
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Subtype
CI-CAN-00002289Explore in graph →
Variants & evidence
7 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| BRD4 Overexpression1 | |||||||
| JQ1 | Predictive | D | Supports Sensitivity Response | 2 | submitted | EID9316Predominantly high-level expression of BRD4 was found in the majority of medulloblastoma cell lines examined (HD-MB3, ONS-76, UW-228, D-341, and D-283); the exception being the Daoy cell line exhibiti… (full text at CIViC) PMID 24231268 · Henssen et al., 2013 · Open in CIViC | civic |
| CTNNB1 Exon 3 Mutation3 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID7967A total of 51 medulloblastomas from two independent cohorts (19 and 32 cases) were assessed for evidence of Wnt/Wg pathway activation, alongside a genome-wide analysis of associated copy-number aberra… (full text at CIViC) PMID 17172831 · Clifford et al., 2006 · Open in CIViC | civic |
| (prognostic) | Prognostic | B | Supports Better Outcome | 4 | submitted | EID9013This retrospective study evaluated 72 pediatric medulloblastoma patients for CTNNB1 mutations (by direct sequencing), copy number alterations (by array-comparative genomic hybridization), and beta-cat… (full text at CIViC) PMID 19197950 · Fattet et al., 2009 · Open in CIViC | civic |
| (diagnostic) | Diagnostic | B | Supports Positive | 3 | accepted | EID7965A series of 72 pediatric medulloblastomas were evaluated for CTNNB1 mutations (by direct sequencing), copy number alterations (by array-comparative genomic hybridization), and beta-catenin protein exp… | |
| CTNNB1 G34R1 | |||||||
| (prognostic) | Prognostic | C | Supports Better Outcome | 3 | submitted | EID9014A retrospective study evaluated 72 pediatric medulloblastoma patients for CTNNB1 mutations (by direct sequencing), copy number alterations (by array-comparative genomic hybridization), and beta-cateni… (full text at CIViC) PMID 19197950 · Fattet et al., 2009 · Open in CIViC | civic |
| CTNNB1 I35K1 | |||||||
| (prognostic) | Prognostic | C | Supports Better Outcome | 3 | submitted | EID9016A retrospective study evaluated 72 pediatric medulloblastoma patients for CTNNB1 mutations (by direct sequencing), copy number alterations (by array-comparative genomic hybridization), and beta-cateni… (full text at CIViC) PMID 19197950 · Fattet et al., 2009 · Open in CIViC | civic |
| CTNNB1 S33F1 | |||||||
| (prognostic) | Prognostic | C | Supports Better Outcome | 4 | submitted | EID9015A retrospective study evaluated 72 pediatric medulloblastoma patients for CTNNB1 mutations (by direct sequencing), copy number alterations (by array-comparative genomic hybridization), and beta-cateni… (full text at CIViC) PMID 19197950 · Fattet et al., 2009 · Open in CIViC | civic |
Data updated 23 hours agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.
PMID 19197950 · Fattet et al., 2009 · Open in CIViC
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