Gene

AURKB

aurora kinase B

Explore in graph →CI-GENE-00021487HGNC:11390 ENSG00000178999 NCBI 9212 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
AURKB Overexpression1
Alisertib + Barasertib + CopanlisibCombination	Head and Neck Squamous Cell Carcinoma	Predictive	D	Supports Sensitivity Response	3	submitted	EID10836 Concurrent inhibition of both AURKB (and AURKA) and PI3K is synergistic in NOTCH1-wild type and NOTCH-1 mutant head and neck squamous cell carcinoma (HNSCC) cell lines. In NOTCH1-wt cell lines, the co… (full text at CIViC) PMID 36169922 · Shah et al., 2022 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (22)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved22 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pediatric Pan-cancer (Columbia U, Genome Med 2016) mixed_pipseq_2017	unmapped	Ssm	14	103	13.6%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.