ATP7B Expression

CI-VAR-00001058Explore in graph →CIViC 5108

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Ovarian Neoplasm4
ATP7B Expression	Amphotericin B	Predictive	D	Supports Sensitivity Response	3	submitted	EID12305 A high-throughput screening (HTS) strategy based on synthetic lethality was used to identify drugs that reduce cisplatin resistance in IGROV-CP20 cells, assessed via an MTT colorimetric assay. Various… (full text at CIViC) PMID 32155756 · Mariniello et al., 2020 · Open in CIViC	civic
ATP7B Expression	Cisplatin	Predictive	D	Supports Resistance	3	submitted	EID12304 To investigate the role of ATP7B in cisplatin resistance, the IGROV-CP20 ovarian cancer cell line was compared to its parental cisplatin-sensitive IGROV line. IGROV-CP20 cells exhibited significantly … (full text at CIViC) PMID 32155756 · Mariniello et al., 2020 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.