ASS1 — gene · CancerIndex

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ASS1 Loss1
Carboplatin + Cisplatin + TaxolSubstitutes	Malignant Ovarian Neoplasm	Predictive	D	Supports Resistance	3	accepted	EID5989 Preclinical evidence for epigenetic inactivation of ASS1 as a determinant of response to platinum chemotherapy suggesting that silencing of ASS1 contributes to treatment failure and clinical relapse i… (full text at CIViC) PMID 19533750 · Nicholson et al., 2009 · Open in CIViC	civic
ASS1 UNDEREXPRESSION1
Chloroquine + PegargiminaseCombination	Sarcoma	Predictive	D	Supports Sensitivity Response	3	accepted

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Upper Tract Urothelial Carcinoma (Cornell/Baylor/MDACC, Nat Commun 2019) utuc_cornell_baylor_mdacc_2019	Renal Pelvis and Ureter Urothelial Carcinoma	Ssm

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas.
· Cell Death Dis · 2016 · PMID 27735949 · validated civic_curation pubmed
Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer.
· Int J Cancer · 2009 · PMID 19533750 · validated civic_curation pubmed