Variant · Snv
ARHGAP35 S866F
CI-VAR-00004142Explore in graph →CIViC 3750
Curated evidence
Evidence by cancer (1 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27646271
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Unmapped disease1unmapped disease | ||||||||
| ARHGAP35 S866F | (functional) | Functional | D | Supports Gain Of Function | 3 | submitted | EID10191A large scale tumor genome analysis identified p190RhoGAP-encoding gene ARHGAP35 to be frequently mutated in endometrial tumours. Mutant and wild-type HA-tagged ARHGAP35 constructs were created and ex… (full text at CIViC) PMID 27646271 · Binamé et al., 2016 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available
No ClinVar interpretation attached to this variant.