ARHGAP35 R997*

CI-VAR-00003938Explore in graph →CIViC 3429

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
ARHGAP35 R997*	(functional)	Functional	D	Supports Loss Of Function	2	submitted	EID9523 A large scale tumor genome analysis identified p190RhoGAP-encoding gene ARHGAP35 to be frequently mutated in endometrial tumours, including the nonsense mutation R997*. Mutant and wild-type HA-tagged … (full text at CIViC) PMID 27646271 · Binamé et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.