Gene

ABCG2

ATP binding cassette subfamily G member 2 (JR blood group)

Explore in graph →CI-GENE-00000109HGNC:74 ENSG00000118777 NCBI 9429 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ABCG2 Q141K1
(prognostic)	Malignant Ovarian Neoplasm	Prognostic	B	Supports Better Outcome	3	accepted	EID671 The ABCG2 Q141K variant was correlated with higher progression-free survival and overall survival in 511 ovarian cancer patients treated with platinum + taxane-based chemotherapy. PMID 22112610 · Tian et al., 2012 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (6)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved6 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cholangiocarcinoma (TCGA, Firehose Legacy) chol_tcga	Cholangiocarcinoma	Ssm	2	35	5.7%	147

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study.
· Gynecol Oncol · 2012 · PMID 22112610 · validated civic_curation pubmed