Cancer Family
Secondary Neoplasm
CI-CAN-00000050Explore in graph →
Non-malignant4,271 active trials56 approved drugs532 evidence items
- NCIt
- C36255
Loading cancer entity…
Cancer Family
CI-CAN-00000050Explore in graph →
Genomics
199 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
237 cases with simple somatic mutation data · 237 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 185 |
| 237 |
| 78.1% |
| cbioportal |
| 3 | CDKN2A | Ssm | 39 | 237 | 16.5% | cbioportal |
| 2 | ARID1A | Ssm | 39 | 237 | 16.5% | cbioportal |
| 5 | PREX2 | Ssm | 24 | 198 | 12.1% | cbioportal |
| 4 | SMARCA4 | Ssm | 25 | 237 | 10.5% | cbioportal |
| 6 | PIK3CA | Ssm | 22 | 237 | 9.3% | cbioportal |
| 9 | SMAD4 | Ssm | 21 | 237 | 8.9% | cbioportal |
| 8 | PTPRD | Ssm | 21 | 237 | 8.9% | cbioportal |
| 7 | ERBB4 | Ssm | 21 | 237 | 8.9% | cbioportal |
| 10 | KMT2D | Ssm | 20 | 237 | 8.4% | cbioportal |
| 11 | APC | Ssm | 19 | 237 | 8% | cbioportal |
| 14 | ZFHX3 | Ssm | 17 | 228 | 7.5% | cbioportal |
| 13 | PTPRT | Ssm | 17 | 237 | 7.2% | cbioportal |
| 12 | KRAS | Ssm | 17 | 237 | 7.2% | cbioportal |
| 15 | EPHA5 | Ssm | 16 | 237 | 6.8% | cbioportal |
| 16 | BRCA2 | Ssm | 15 | 237 | 6.3% | cbioportal |
| 22 | KMT2B | Ssm | 12 | 198 | 6.1% | cbioportal |
| 17 | ARID2 | Ssm | 13 | 237 | 5.5% | cbioportal |
| 18 | KMT2A | Ssm | 13 | 237 | 5.5% | cbioportal |
| 23 | PTPRS | Ssm | 12 | 237 | 5.1% | cbioportal |
| 21 | ERBB2 | Ssm | 12 | 237 | 5.1% | cbioportal |
| 19 | AR | Ssm | 12 | 237 | 5.1% | cbioportal |
| 20 | CREBBP | Ssm | 12 | 237 | 5.1% | cbioportal |
| 30 | NTRK3 | Ssm | 11 | 237 | 4.6% | cbioportal |
| 27 | IRS2 | Ssm | 11 | 237 | 4.6% | cbioportal |
| 26 | FLT4 | Ssm | 11 | 237 | 4.6% | cbioportal |
| 29 | NOTCH1 | Ssm | 11 | 237 | 4.6% | cbioportal |
| 31 | RNF43 | Ssm | 11 | 237 | 4.6% | cbioportal |
| 24 | CIC | Ssm | 11 | 237 | 4.6% | cbioportal |
| 25 | ERBB3 | Ssm | 11 | 237 | 4.6% | cbioportal |
Data updated 22 days agoSource updated 2026-01-07