Precursor Lymphoid Neoplasm

Lentiviral-mediated overexpression of PRPS1 L191F in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC)

PMID 25962120 · Li et al., 2015 · Open in CIViC

Lentiviral-mediated overexpression of PRPS1 L191F in Reh cells resulted no difference in response to Methotrexate, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS1 overexpres… (full text at CIViC)

PMID 25962120 · Li et al., 2015 · Open in CIViC

Lentiviral-mediated overexpression of PRPS1 N144S in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC)

PMID 25962120 · Li et al., 2015 · Open in CIViC

Lentiviral-mediated overexpression of PRPS1 N144S in Reh cells resulted no difference in response to Methotrexate, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS1 overexpres… (full text at CIViC)

PMID 25962120 · Li et al., 2015 · Open in CIViC

Lentiviral-mediated overexpression of PRPS1 S103N in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS… (full text at CIViC)

PMID 25962120 · Li et al., 2015 · Open in CIViC

Lentiviral-mediated overexpression of PRPS1 S103T in Reh cells resulted in significant resistance against mercaptopurine (6-MP) and thioguanine (6-TG) as indicated by IC50 increases and reduced apopto… (full text at CIViC)

PMID 25962120 · Li et al., 2015 · Open in CIViC

Lentiviral-mediated overexpression of PRPS1 S103T in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS… (full text at CIViC)

PMID 25962120 · Li et al., 2015 · Open in CIViC

Lentiviral-mediated overexpression of PRPS1 T303S in Reh cells resulted no difference in response to Methotrexate, Cytarabine, Daunorubicin, or L-Asparginase compared to empty vector and wildtype PRPS… (full text at CIViC)

PMID 25962120 · Li et al., 2015 · Open in CIViC

This retrospective study reported the outcome of 24 patients with Ph-like acute lymphoblastic leukemia (Ph-like ALL) harboring ABL-class fusions, who were treated with a combination of tyrosine kinase… (full text at CIViC)

PMID 31434701 · Tanasi et al., 2019 · Open in CIViC

The study evaluated 15 B-ALL cases which were previously identified as Ph-like using prediction analysis of microarrays (PAM). Paired-end messenger RNA sequencing (RNA-seq) was performed to identify u… (full text at CIViC)

PMID 22897847 · Roberts et al., 2012 · Open in CIViC

De Braekeleer et al. reported a 11-yr-old boy with pre-B ALL associated with a t(1;9)(q24;q34) translocation. FISH analysis using bacterial artificial chromosome (BAC) clones showed colocalization of … (full text at CIViC)

PMID 17541395 · De Braekeleer et al., 2007 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (6.9 years old) with a… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

Authors reported a 40-yr-old male patient with pre-B ALL and t(1;9)(q24;q34) translocation. Two different RCSD1-ABL1 fusion transcripts, presumably resulting from alternative splicing, were identified… (full text at CIViC)

PMID 19794096 · Mustjoki et al., 2009 · Open in CIViC

Author reported a 31-year-old male patient diagnosed with B-ALL. RT-PCR and sequence analyses detected transcription of a single RCSD1-ABL1 fusion gene variant, which had breakpoints in exon 3 of RCSD… (full text at CIViC)

PMID 21863287 · Inokuchi et al., 2011 · Open in CIViC

Authors reported a 61-year old female diagnosed with B-ALL in August 2012. The RCSD1-ABL1 t(1;9)(q22;q34) fusion between exon 3 of RCSD1 and exon 4 of ABL1 was identified by RT-PCR. The patient was en… (full text at CIViC)

PMID 28057740 · Frech et al., 2017 · Open in CIViC

Authors reported a 15-year-old female patient with B-ALL diagnosed in June 2014. Conventional cytogenetics and FISH identified t(1;9)(q23;q34) and RCSD1ABL1 fusion. Microarray identified an approximat… (full text at CIViC)

PMID 26600955 · Kamran et al., 2015 · Open in CIViC

The ABL1-RCSD1 fusion was identified in a 6 yo boy with Ph-like B-ALL and hyperleukocytosis. Following standard induction therapy the patient had an MRD of 16.4% in bone marrow, indicating a poor resp… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The RCSD1-ABL1 fusion was identified in a 6 yo boy with Ph-like B-ALL (expression signature verified by low density gene expression array) and hyperleukocytosis. Following standard induction therapy t… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

This case report describes a 15 year old patient with relapsed B-ALL positive for the RCSD1-ABL1 fusion, who was successfully treated with chemotherapy with addition of imatinib; the patient remained … (full text at CIViC)

PMID 27125982 · Perwein et al., 2016 · Open in CIViC

Authors reported a 26 year-old female patient with B-ALL and RCSD1-ABL1 fusion identified by FISH and PCR. Sequencing showed that RCSD1 exon 3 was fused to ABL1 exon 4. This patient was treated with c… (full text at CIViC)

PMID 25768406 · Collette et al., 2015 · Open in CIViC

The authors performed an ex vivo functional evaluation of the drug response profiling (DRP) of the leukemic blasts from a B-ALL patient with RCSD1-ABL1 fusion with a specific focus on TKIs. Resistance… (full text at CIViC)

PMID 25768406 · Collette et al., 2015 · Open in CIViC

Authors reported a 15-year-old female diagnosed with B-ALL with the t(1;9)(q24;q34.1). RNAseq data were consistent with a fusion between the exon 3 of RCSD1 and exon 4 of ABL1, resulting in the format… (full text at CIViC)

PMID 27855558 · Yap et al., 2017 · Open in CIViC

In a study of Transcriptome sequencing to identify fusions and mutations on 560 ALL Patients enrolled on a multi-center Alliance, two patients were identified to carry the RCSD1-ABL2 fusion. One was a… (full text at CIViC)

PMID 27824051 · Gu et al., 2016 · Open in CIViC

A 20-year-old male patient was diagnosed with precursor B-ALL (immunophenotype: CD34+, DR+, TdT+, CD19+, CD20 partial+, CD10+, cyCD79a+, CD24+, surface/cyCD22+, cyIgM+, sIg−, MPO−, CD13+, CD33+). Chro… (full text at CIViC)

PMID 25098428 · Raca et al., 2015 · Open in CIViC

In a study of 1389 consecutively enrolled, newly diagnosed patients with B-ALL, two male patients with high risk Ph-like disease were identified to carry RCSD1-ABL2 fusion by RT-PCR and are eligible t… (full text at CIViC)

PMID 28408464 · Reshmi et al., 2017 · Open in CIViC