Cancer Family
Mesenchymal Cell Neoplasm
CI-CAN-00000027Explore in graph →
Non-malignant413 active trials10 approved drugs208 evidence items
- NCIt
- C7059
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Cancer Family
CI-CAN-00000027Explore in graph →
Genomics
12 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
499 cases with simple somatic mutation data · 499 cases total · 2026-01-07 · mapped to Gastrointestinal Stromal Tumor EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KIT |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 384 |
| 499 |
| 77% |
| cbioportal |
| 2 | PDGFRA | Ssm | 49 | 499 | 9.8% | cbioportal |
| 3 | TP53 | Ssm | 21 | 499 | 4.2% | cbioportal |
| 4 | NF1 | Ssm | 20 | 499 | 4% | cbioportal |
| 5 | SETD2 | Ssm | 20 | 499 | 4% | cbioportal |
| 6 | MGA | Ssm | 18 | 479 | 3.8% | cbioportal |
| 7 | MAX | Ssm | 17 | 499 | 3.4% | cbioportal |
| 10 | CSDE1 | Ssm | 12 | 374 | 3.2% | cbioportal |
| 8 | RB1 | Ssm | 15 | 499 | 3% | cbioportal |
| 11 | KMT2B | Ssm | 10 | 374 | 2.7% | cbioportal |
| 9 | PTEN | Ssm | 13 | 499 | 2.6% | cbioportal |
| 12 | SDHA | Ssm | 10 | 499 | 2% | cbioportal |
| 13 | TSC1 | Ssm | 10 | 499 | 2% | cbioportal |
| 14 | PIK3CA | Ssm | 9 | 499 | 1.8% | cbioportal |
| 123 | CYP19A1 | Ssm | 1 | 66 | 1.5% | cbioportal |
| 186 | REST | Ssm | 1 | 66 | 1.5% | cbioportal |
| 100 | ALB | Ssm | 1 | 66 | 1.5% | cbioportal |
| 15 | ARID1A | Ssm | 7 | 499 | 1.4% | cbioportal |
| 16 | ATM | Ssm | 7 | 499 | 1.4% | cbioportal |
| 18 | KMT2C | Ssm | 6 | 499 | 1.2% | cbioportal |
| 17 | CBL | Ssm | 6 | 499 | 1.2% | cbioportal |
| 19 | MTOR | Ssm | 6 | 499 | 1.2% | cbioportal |
| 21 | ROS1 | Ssm | 5 | 499 | 1% | cbioportal |
| 20 | CREBBP | Ssm | 5 | 499 | 1% | cbioportal |
| 22 | ANKRD11 | Ssm | 4 | 479 | 0.8% | cbioportal |
| 23 | ATRX | Ssm | 4 | 499 | 0.8% | cbioportal |
| 25 | GRIN2A | Ssm | 4 | 499 | 0.8% | cbioportal |
| 26 | IRS2 | Ssm | 4 | 499 | 0.8% | cbioportal |
| 27 | JAK1 | Ssm | 4 | 499 | 0.8% | cbioportal |
| 24 | DNMT3A | Ssm | 4 | 499 | 0.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07