Malignant Pharyngeal Neoplasm — Variants & evidence

Malignant Pharyngeal Neoplasm — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items (4 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CD274 Expression1
Nivolumab	Malignant Nasopharyngeal NeoplasmALIAS	Predictive	B	Supports Sensitivity Response	1	submitted	EID9010 In a Clinic Phase 2 Consortium, 44 patients with metastatic nasopharyngeal carcinoma had an overall response rate (ORR) to nivolumab of 20.5%; 1 complete response lasting over 12 months; 8 partial res… (full text at CIViC) PMID 29584545 · Ma et al., 2018 · Open in CIViC	civic
CDKN2A p16 Expression2
(prognostic)	Malignant Oropharyngeal NeoplasmALIAS	Prognostic	A	Supports Better Outcome	4	accepted	EID758 720 patients with stage III/IV oropharyngeal cancer were retrospectively analyzed for p16 and HPV status. p16 and HPV-positivity correlated well and both showed improved overall-survival compared to p… (full text at CIViC) PMID 20530316 · Ang et al., 2010 · Open in CIViC	civic
Cetuximab	Malignant Oropharyngeal NeoplasmALIAS	Predictive	B	Does Not Support Resistance	4	accepted	EID759 This study shows that benefit of EGFR inhibition in addition to radiotherapy was independent of p16/HPV status. 182 patients were evaluated. PMID 26712222 · Rosenthal et al., 2016 · Open in CIViC	civic
FGFR3 K508M1
(oncogenic)	Malignant Nasopharyngeal NeoplasmALIAS	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11797 Paper analysing FGFR3-TACC3 frequency and oncogenicity in nasopharyngeal carcinoma. FGFR3-TACC3-K508M in HNE1 and HK1 NPC cell lines showed a significant reduction of cellular proliferation in the col… (full text at CIViC) PMID 25535896 · Yuan et al., 2014 · Open in CIViC	civic

Data updated 7 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.