FGFR3 K508M

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Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Bladder Carcinoma1
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11803 The study found that TGFβ-activated kinase 1 (TAK1) is a novel protein that interacts and is targeted by FGFR3 kinase activity. Activating mutations in FGFR3 modulate expression of genes that regulate… (full text at CIViC) PMID 24466111 · Salazar et al., 2014 · Open in CIViC	civic
Glioblastoma1
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11806 Rat1A astrocytes cells expressing the FGFR3-TACC3-K508M were tested to evaluate anchorage-independent growth in soft agar (Fig. 2A and table S5) and did not show an ability to grow evidenced by no col… (full text at CIViC) PMID 22837387 ·

Molecular profile

Therapy

Type

Level

Direction · significance

Rating (1–5)

Status

Evidence

Source

Bladder Carcinoma1

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11803

The study found that TGFβ-activated kinase 1 (TAK1) is a novel protein that interacts and is targeted by FGFR3 kinase activity. Activating mutations in FGFR3 modulate expression of genes that regulate… (full text at CIViC)

PMID 24466111 · Salazar et al., 2014 · Open in CIViC

civic

Glioblastoma1

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11806

Rat1A astrocytes cells expressing the FGFR3-TACC3-K508M were tested to evaluate anchorage-independent growth in soft agar (Fig. 2A and table S5) and did not show an ability to grow evidenced by no col… (full text at CIViC)

PMID 22837387 ·

Malignant Cervical Neoplasm1
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11799 A study that aims to analyse the biological significance of the FGFR3-TACC3 fusion. They transfected the K508M (also referred to as KD or kinase-dead) FGFR3-TACC3 fusion transcript into cervical epith… (full text at CIViC) PMID 29358619 · Tamura et al., 2018 · Open in CIViC	civic

Malignant Cervical Neoplasm1

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11799

A study that aims to analyse the biological significance of the FGFR3-TACC3 fusion. They transfected the K508M (also referred to as KD or kinase-dead) FGFR3-TACC3 fusion transcript into cervical epith… (full text at CIViC)

PMID 29358619 · Tamura et al., 2018 · Open in CIViC

civic

Malignant Nasopharyngeal Neoplasm1
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11797 Paper analysing FGFR3-TACC3 frequency and oncogenicity in nasopharyngeal carcinoma. FGFR3-TACC3-K508M in HNE1 and HK1 NPC cell lines showed a significant reduction of cellular proliferation in the col… (full text at CIViC) PMID 25535896 · Yuan et al., 2014 · Open in CIViC	civic

Malignant Nasopharyngeal Neoplasm1

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11797

Paper analysing FGFR3-TACC3 frequency and oncogenicity in nasopharyngeal carcinoma. FGFR3-TACC3-K508M in HNE1 and HK1 NPC cell lines showed a significant reduction of cellular proliferation in the col… (full text at CIViC)

PMID 25535896 · Yuan et al., 2014 · Open in CIViC

civic

Malignant Neoplasm3
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11800 cDNAs encoding wild-type FGFR3 and other variants such as the kinse dead K508M (F3-B-KD) were inserted into the pCXND3 vector and used to transfect cells. No phosphorylation of the K508M variant was d… (full text at CIViC) PMID 25589496 · Nakanishi et al., 2015 · Open in CIViC	civic
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11802 Study show that the FGFR3-TACC3 (F3-T3) fusion triggers peroxisome biogenesis and new protein synthesis, enabling mitochondrial respiration and tumor growth. They expressed F3-T3 fusion in immortalize… (full text at CIViC) PMID 29323298 · Frattini et al., 2018 · Open in CIViC	civic
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11805 Authors wanted to determine Ship2 role in FGF-mediated cell migration. They used the CRISPR/Cas9 system to disrupt the Ship2 gene in RCS cells. They found that loss of SHIP2 converted FGF-mediated sus… (full text at CIViC) PMID 30228226 · Fafilek et al., 2018 · Open in CIViC	civic

Malignant Neoplasm3

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11800

cDNAs encoding wild-type FGFR3 and other variants such as the kinse dead K508M (F3-B-KD) were inserted into the pCXND3 vector and used to transfect cells. No phosphorylation of the K508M variant was d… (full text at CIViC)

PMID 25589496 · Nakanishi et al., 2015 · Open in CIViC

civic

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11802

Study show that the FGFR3-TACC3 (F3-T3) fusion triggers peroxisome biogenesis and new protein synthesis, enabling mitochondrial respiration and tumor growth. They expressed F3-T3 fusion in immortalize… (full text at CIViC)

PMID 29323298 · Frattini et al., 2018 · Open in CIViC

civic

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11805

Authors wanted to determine Ship2 role in FGF-mediated cell migration. They used the CRISPR/Cas9 system to disrupt the Ship2 gene in RCS cells. They found that loss of SHIP2 converted FGF-mediated sus… (full text at CIViC)

PMID 30228226 · Fafilek et al., 2018 · Open in CIViC

civic

Multiple Myeloma1
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11804 The study found that FGFR3 interacts with a regulatory subunit of PI3K, and this interaction negatively regulates the Ras/ERK/MAPK pathway in response to FGFR3 activity. This interaction could be a po… (full text at CIViC) PMID 19286672 · Salazar et al., 2009 · Open in CIViC	civic

Multiple Myeloma1

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11804

The study found that FGFR3 interacts with a regulatory subunit of PI3K, and this interaction negatively regulates the Ras/ERK/MAPK pathway in response to FGFR3 activity. This interaction could be a po… (full text at CIViC)

PMID 19286672 · Salazar et al., 2009 · Open in CIViC

civic

Pancreatic Ductal Adenocarcinoma1
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11798 The study analysed the expression of the two splice variants of FGFR3 (FGFR3-IIIb and FGFR3-IIIc/FGFR3-IIIc-KD) in two pancreatic ductal adenocarcinoma cell lines (Capan-2 and BxPC-3). The FGFR3-IIIc-… (full text at CIViC) PMID 23902722 · Lafitte et al., 2013 · Open in CIViC	civic

Pancreatic Ductal Adenocarcinoma1

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11798

The study analysed the expression of the two splice variants of FGFR3 (FGFR3-IIIb and FGFR3-IIIc/FGFR3-IIIc-KD) in two pancreatic ductal adenocarcinoma cell lines (Capan-2 and BxPC-3). The FGFR3-IIIc-… (full text at CIViC)

PMID 23902722 · Lafitte et al., 2013 · Open in CIViC

civic

Osteochondrodysplasia2unmapped disease
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	1	submitted	EID11801 HeLa, 293T and RCS cells were transfected with N540K, G380R, R248C, Y373C, K650M, K650E and K508M to test STAT1(Y701) activation. The assay showed no activation in cells transfected with the kinase-in… (full text at CIViC) PMID 19088846 · Krejci et al., 2008 · Open in CIViC	civic
FGFR3 K508M	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	2	submitted	EID11807 A study was conducted to analyze the impact of mutations in the transmembrane and kinase domains that cause skeletal dysplasias. The study used PC12 cells with FGFR3 variants that were introduced by s… (full text at CIViC) PMID 9857065 · Raffioni et al., 1998 · Open in CIViC	civic

Osteochondrodysplasia2unmapped disease

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11801

HeLa, 293T and RCS cells were transfected with N540K, G380R, R248C, Y373C, K650M, K650E and K508M to test STAT1(Y701) activation. The assay showed no activation in cells transfected with the kinase-in… (full text at CIViC)

PMID 19088846 · Krejci et al., 2008 · Open in CIViC

civic

FGFR3 K508M

(oncogenic)

Oncogenic

Does Not Support Oncogenicity

submitted

EID11807

A study was conducted to analyze the impact of mutations in the transmembrane and kinase domains that cause skeletal dysplasias. The study used PC12 cells with FGFR3 variants that were introduced by s… (full text at CIViC)

PMID 9857065 · Raffioni et al., 1998 · Open in CIViC

civic

Unmapped disease1unmapped disease
FGFR3 K508M	(functional)	Functional	D	Supports Loss Of Function	2	submitted	EID11796 This study used micropatterned surfaces to enrich fluorophore-tagged FGFR3 in specific areas of the plasma membrane. Researchers quantified receptor activation by capturing cellular activity using tot… (full text at CIViC) PMID 36581204 · Hartl et al., 2023 · Open in CIViC	civic

Unmapped disease1unmapped disease

FGFR3 K508M

(functional)

Functional

Supports Loss Of Function

submitted

EID11796

This study used micropatterned surfaces to enrich fluorophore-tagged FGFR3 in specific areas of the plasma membrane. Researchers quantified receptor activation by capturing cellular activity using tot… (full text at CIViC)

PMID 36581204 · Hartl et al., 2023 · Open in CIViC

civic

Evidence by cancer (12 items)

Clinical significance (0)