Malignant Germ Cell Tumor — Variants & evidence

Malignant Germ Cell Tumor — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

2 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items (2 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
LEUTX Fusion1
(diagnostic)	Childhood Central Nervous System Embryonal CarcinomaALIAS	Diagnostic	B	Supports Positive	2	submitted	EID12698 Across a multicenter cohort of CNS embryonal tumors (n = 9), recurrent BRD4::LEUTX fusions were identified by RNA sequencing, with all cases retaining LEUTX exon 2 and variable BRD4 breakpoints (exons… (full text at CIViC) PMID 38500181 · Andreiuolo et al., 2024 · Open in CIViC	civic
LEUTX Fusion1
(diagnostic)	Childhood Central Nervous System Embryonal CarcinomaALIAS	Diagnostic	C	Supports Positive	2	submitted	EID10310 This is a report about CIC-LEUTX gene fusion (CIC exon 20 to LEUTX exon 3 ) in a CNS embryonal tumor from a 2-year-old male, and the report also reviewed the clinical and pathological features of 3 ot… (full text at CIViC) PMID 33344249 · Hu et al., 2020 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.