Cancer
Malignant Esophageal Neoplasm
CI-CAN-00001127Explore in graph →
Top-level518 active trials6 approved drugs12 evidence items
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Cancer
CI-CAN-00001127Explore in graph →
Clinical trials
1,926 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (169)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT04543617 | A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy(SKYSCRAPER-07) | completed | Phase 3 | 760 | Hoffmann-La RocheINDUSTRY | 28 | Sep 14, 2026 | clinicaltrials |
| NCT04540211 | A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma(SKYSCRAPER-08) | completed | Phase 3 |
| 461 |
| Hoffmann-La RocheINDUSTRY |
| 5 |
| Aug 27, 2026 |
| clinicaltrials |
| NCT04210115 | Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975) | completed | Phase 3 | 703 | Merck Sharp & Dohme LLCINDUSTRY | 27 | Jul 22, 2026 | clinicaltrials |
| NCT01196390 | Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer | completed | Phase 3 | 203 | National Cancer Institute (NCI)NIH | 1 | Jun 2, 2026 | clinicaltrials |
| NCT02872116 | Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Against Chemotherapy in Stomach Cancer or Stomach/Esophagus Junction Cancer(CheckMate649) | completed | Phase 3 | 2,031 | Bristol-Myers SquibbINDUSTRY | 29 | Aug 7, 2025 | clinicaltrials |
| NCT03783442 | A Study of Tislelizumab (BGB-A317) in Combination With Chemotherapy as First Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma | completed | Phase 3 | 649 | BeiGeneINDUSTRY | 16 | Jul 29, 2025 | clinicaltrials |
| NCT00357682 | A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia(AspECT) | completed | Phase 3 | 2,557 | University of OxfordOTHER | 0 | May 1, 2025 | clinicaltrials |
| NCT01249352 | A Study of Chemoradiation Associated with Nimotuzumab As the Treatment of Locally Advanced Esophageal Cancer(NICE) | completed | Phase 2 / Phase 3 | 104 | Eurofarma Laboratorios S.A.INDUSTRY | 1 | Mar 31, 2025 | clinicaltrials |
| NCT02349412 | Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers | completed | Phase 3 | 405 | Alliance for Clinical Trials in OncologyOTHER | 1 | Feb 7, 2025 | clinicaltrials |
| NCT04499924 | Tucatinib, Trastuzumab, Ramucirumab, and Paclitaxel Versus Paclitaxel and Ramucirumab in Previously Treated HER2+ Gastroesophageal Cancer(MOUNTAINEER-02) | completed | Phase 2 / Phase 3 | 17 | Seagen Inc.INDUSTRY | 6 | Jan 22, 2025 | clinicaltrials |
| NCT06775652 | Neoadjuvant Chemoradiotherapy Plus Surgery vs. Surgery Plus Adjuvant Therapy for ESCC(ESCC) | completed | Phase 3 | 254 | Yongtao HanOTHER | 1 | Jan 15, 2025 | clinicaltrials |
| NCT03430843 | A Study of Tislelizumab (BGB-A317) Versus Chemotherapy as Second Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma | completed | Phase 3 | 512 | BeiGeneINDUSTRY | 11 | Oct 26, 2024 | clinicaltrials |
| NCT05369234 | Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis | completed | Phase 3 | 100 | Covenant Health Cancer CenterOTHER | 1 | Oct 10, 2024 | clinicaltrials |
| NCT01404156 | Preoperative Chemotherapy vs. Chemoradiation in Esophageal / GEJ Adenocarcinoma(POWERRANGER) | completed | Phase 2 / Phase 3 | 29 | Dr. Gordon BuduhanOTHER | 1 | Aug 28, 2024 | clinicaltrials |
| NCT03099382 | Study of SHR-1210 Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal Cancer | completed | Phase 3 | 457 | Jiangsu HengRui Medicine Co., Ltd.INDUSTRY | 1 | Jan 22, 2024 | clinicaltrials |
| NCT03600831 | Postoperative Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Patients With Locoregionally Advanced Esophageal Squamous Cell Carcinoma | completed | Phase 2 / Phase 3 | 434 | Huai'an First People's HospitalOTHER | 1 | Jan 9, 2024 | clinicaltrials |
| NCT04187352 | A Study of CS1001 in Subjects With Esophageal Squamous Cell Carcinoma | completed | Phase 3 | 540 | CStone PharmaceuticalsINDUSTRY | 1 | Nov 24, 2023 | clinicaltrials |
| NCT03748134 | Sintilimab or Placebo With Chemotherapy in Esophageal Squamous Cell Carcinoma ( ORIENT-15 ) | completed | Phase 3 | 746 | Innovent Biologics (Suzhou) Co. Ltd.INDUSTRY | 7 | Oct 24, 2023 | clinicaltrials |
| NCT02853474 | Early Palliative Care in Patients With Metastatic Upper Gastrointestinal Cancers Treated With First-line Chemotherapy(EPIC-1511) | completed | Phase 3 | 480 | Centre Oscar LambretOTHER | 1 | Apr 26, 2023 | clinicaltrials |
| NCT02564263 | Study of Pembrolizumab (MK-3475) Versus Investigator's Choice Standard Therapy for Participants With Advanced Esophageal/ Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181) | completed | Phase 3 | 628 | Merck Sharp & Dohme LLCINDUSTRY | 0 | Mar 13, 2023 | clinicaltrials |
| NCT03691090 | Study of SHR-1210 in Combination With Chemotherapy in Advanced Esophageal Cancer | completed | Phase 3 | 596 | Jiangsu HengRui Medicine Co., Ltd.INDUSTRY | 1 | Dec 7, 2022 | clinicaltrials |
| NCT02569242 | Study of Nivolumab in Unresectable Advanced or Recurrent Esophageal Cancer | completed | Phase 3 | 419 | Ono Pharmaceutical Co., Ltd.INDUSTRY | 8 | Jul 6, 2022 | clinicaltrials |
| NCT00655876 | Paclitaxel, Cisplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Locally Advanced Esophageal Cancer | completed | Phase 3 | 344 | Radiation Therapy Oncology GroupNETWORK | 2 | Jun 14, 2022 | clinicaltrials |
| NCT01137123 | Improve the Treatment of Thoracic Esophageal Cancer | completed | Phase 3 | 301 | Sun Yat-sen UniversityOTHER | 1 | Mar 31, 2022 | clinicaltrials |
| NCT02459457 | A Comparison of Paclitaxel-based Three Regimens Concurrent With Radiotherapy for Patients With Local Advanced Esophageal Cancer | completed | Phase 3 | 321 | Fudan UniversityOTHER | 1 | Feb 9, 2022 | clinicaltrials |
| NCT04196075 | The Effect of Andrographis Paniculata (AP) on Palliative Management of Advanced Esophageal Cancer(AP) | completed | Phase 3 | 30 | Chinese University of Hong KongOTHER | 1 | Nov 8, 2021 | clinicaltrials |
| NCT00487695 | Confocal Endomicroscopy for Barrett's Esophagus(CEBE) | completed | Phase 3 | 46 | Johns Hopkins UniversityOTHER | 1 | Jun 22, 2021 | clinicaltrials |
| NCT00002883 | Surgery With or Without Combination Chemotherapy in Treating Patients With Cancer of the Esophagus | completed | Phase 3 | 250 | UNICANCEROTHER | 1 | Feb 23, 2021 | clinicaltrials |
| NCT02644408 | Megestrol Acetate for the Improvement of Quality of Life in Esophageal Cancer With Chemoradiotherapy | completed | Phase 3 | 184 | The First Affiliated Hospital of Henan University of Science and TechnologyOTHER | 1 | Feb 17, 2021 | clinicaltrials |
| NCT01107639 | Radiation Therapy and Chemotherapy, With or Without Cetuximab, Followed by Surgery in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed by Surgery | completed | Phase 3 | 297 | Swiss Cancer InstituteOTHER | 5 | Oct 20, 2020 | clinicaltrials |
| NCT02813967 | S-1 Concurrent With Radiotherapy Versus Radiotherapy for Elderly Patients With Esophageal Cancer | completed | Phase 3 | 298 | Zhejiang Cancer HospitalOTHER | 1 | Sep 16, 2020 | clinicaltrials |
| NCT00020787 | Vaccine Therapy Plus Chemotherapy in Treating Patients With Metastatic or Locally Recurrent Stomach Cancer or Esophageal Cancer | completed | Phase 3 | 8 | Jonsson Comprehensive Cancer CenterOTHER | 1 | Aug 3, 2020 | clinicaltrials |
| NCT00052910 | Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer | completed | Phase 3 | 546 | Alliance for Clinical Trials in OncologyOTHER | 2 | May 7, 2020 | clinicaltrials |
| NCT00047112 | Surgery With or Without Radiation Therapy and Chemotherapy in Treating Patients With Esophageal Cancer | completed | Phase 3 | 195 | Federation Francophone de Cancerologie DigestiveOTHER | 4 | Mar 30, 2020 | clinicaltrials |
| NCT01544790 | Robot-assisted Thoraco-laparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy(ROBOT) | completed | Phase 3 | 112 | UMC UtrechtOTHER | 1 | Mar 26, 2020 | clinicaltrials |
| NCT02399306 | Chemoradiotherapy With or Without Enteral Nutrition for Locally Advanced Thoracic Esophageal Carcinoma | completed | Phase 3 | 222 | Sichuan Cancer Hospital and Research InstituteOTHER | 1 | Mar 17, 2020 | clinicaltrials |
| NCT01348217 | Radiochemotherapy With and Without Dose Escalation in Patients Presenting Locally Advanced or Inoperable Carcinoma of the Oesophagus(CONCORDE) | completed | Phase 2 / Phase 3 | 196 | Centre Georges Francois LeclercOTHER | 1 | Jan 27, 2020 | clinicaltrials |
| NCT01591135 | A Phase III Study of Comparing Paclitaxel Plus 5-Fluorouracil Versus Cisplatin Plus 5-Fluorouracil in Chemoradiotherapy for Locally Advanced Esophageal Carcinoma | completed | Phase 3 | 436 | Fudan UniversityOTHER | 1 | Oct 18, 2018 | clinicaltrials |
| NCT00160875 | Pre-operative Chemo (CPT11, Cisplatin), Radiotherapy, Plus Surgery for Resectable Esophageal Cancer | completed | Phase 2 / Phase 3 | 54 | University Health Network, TorontoOTHER | 1 | May 4, 2017 | clinicaltrials |
| NCT00003118 | Surgery With or Without Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus | completed | Phase 3 | 56 | Alliance for Clinical Trials in OncologyOTHER | 1 | Jul 4, 2016 | clinicaltrials |
| NCT00861094 | Radiation Therapy + Combination Chemotherapy as 1st-Line Therapy for Patients With Inoperable Esophageal Cancer | completed | Phase 2 / Phase 3 | 266 | UNICANCEROTHER | 1 | Dec 18, 2015 | clinicaltrials |
| NCT01998230 | Early Oral Feeding Following Thoracolaparoscopic Oesophagectomy in Patients With Esophageal Cancer | completed | Phase 3 | 280 | Yin LiOTHER_GOV | 1 | Oct 16, 2015 | clinicaltrials |
| NCT00416858 | Radiation Therapy and Combination Chemotherapy With or Without Surgery in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed By Surgery | completed | Phase 3 | 40 | Federation Francophone de Cancerologie DigestiveOTHER | 0 | Mar 4, 2014 | clinicaltrials |
| NCT00002631 | Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Cancer of the Esophagus | completed | Phase 3 | 298 | Radiation Therapy Oncology GroupNETWORK | 2 | Nov 19, 2013 | clinicaltrials |
| NCT00002897 | Surgery With or Without Chemotherapy in Treating Patients With Stage II or Stage III Cancer of the Esophagus | completed | Phase 3 | 240 | European Institute of OncologyOTHER | 1 | Sep 20, 2013 | clinicaltrials |
| NCT00978549 | Symptom Control With or Without Docetaxel in Treating Patients With Relapsed Esophageal Cancer or Stomach Cancer | completed | Phase 3 | 320 | Cambridge University Hospitals NHS Foundation TrustOTHER | 1 | Aug 7, 2013 | clinicaltrials |
| NCT00002930 | PET Scan in Patients With Lung and Esophageal Cancers That May Be Removed by Surgery | completed | Phase 2 / Phase 3 | 75 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Jan 18, 2013 | clinicaltrials |
| NCT00525200 | p53-Adjusted Neoadjuvant Chemotherapy for Potentially Resectable Esophageal Cancer(PANCHO) | completed | Phase 3 | 170 | Daniela KandiolerOTHER | 1 | Dec 21, 2012 | clinicaltrials |
Data updated 16 days agoSource updated Sep 14, 2026source: clinicaltrials