Clinical trial · Interventional
Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis
Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis: a Single-blind Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
As mentioned above, several prior studies have shown the positive effects of oral use of aloe vera juice in managing chemotherapy and radiation-induced oral mucositis and esophagitis. This study aims to add to the existing body of research around aloe vera juice and its effects on oral mucositis and esophagitis. The intention is to determine whether aloe vera juice should be considered as part of standard treatment.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chest Wall Tumor | Chest Wall Neoplasm | ALIAS | 0.90 |
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Head and Neck Cancers - Tonsils | — | UNRESOLVED | — |
| Laryngeal Cancer | Malignant Laryngeal Neoplasm | CURATED_EXACT | 0.92 |
| Mediastinal Cancer | Malignant Mediastinal Neoplasm | ALIAS | 0.90 |
| Oral Cavity Cancer | Malignant Oral Cavity Neoplasm | CURATED_BROADER | 0.80 |
| Oropharynx Cancer | Malignant Oropharyngeal Neoplasm | ALIAS | 0.90 |
| Radiation Mucositis | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 100% Aloe Vera Juice | Dietary Supplement | — | UNRESOLVED |
| Carafate | Drug | — | UNRESOLVED |
| Magic Mouthwash | Combination Product | — | UNRESOLVED |
| Salt and Baking soda rinse | Combination Product | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Cohort 1--Arm 1
- description
- Aloe Vera Juice + Standard of Care Treatments Swish and spit ¼ cup (2 ounces) of 100% aloe vera juice 3 times per day, 7 days per week as first line treatment, standard of care agents added as needed
- interventionNames
- Dietary Supplement: 100% Aloe Vera Juice
- Combination Product: Magic Mouthwash
- Combination Product: Salt and Baking soda rinse
- Drug: Carafate
- type
- ACTIVE_COMPARATOR
- label
- Cohort 1--Arm 2
- description
- Standard of Care Treatments Use salt and baking soda rinses, Magic Mouthwash, Carafate, etc.
- interventionNames
- Combination Product: Magic Mouthwash
- Combination Product: Salt and Baking soda rinse
- Drug: Carafate
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * must have signed and dated an IRB approved consent form that conforms to federal and institutional guidelines * Age \>/= 18 years * Confirmed lip, oral cavity, hard palate, tongue, tonsil, pharyngeal, neck, esophageal, mediastinal, and/or chest wall cancers * Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. * Men treated or enrolled on this protocol must agree to use adequate contraception prior to the study, for the duration of study participation. Exclusion Criteria: * Patients who are not on concurrent chemotherapy and radiation. * History of allergic reactions attributed to compounds of similar chemical or biologic composition to aloe vera juice. * Patients with psychiatric illness/social situations that would limit compliance with study requirements. * Pregnant women or women who are breastfeeding
References
Publications (0)
Data not yet available