Chemoradiotherapy With or Without Enteral Nutrition for Locally Advanced Thoracic Esophageal Carcinoma

Inclusion Criteria:

* 18 to 75 years old
* male or femalePathologically or cytologically proven esophageal squamous cell carcinoma
* Clinical stage II or stage III
* PG-SGA≧2
* Karnofsky performance score(KPS) ≧70
* Estimated life expectancy of at least 12 weeks
* Hemoglobin≥90.0g/dL,white blood cell count（WBC）≥ 4000 cells/mm³,Platelet count≥100,000 cells/mm³
* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \< 2.5 times upper limit of normal,bilirubin normal
* Creatinine normal OR creatinine clearance ≥ 60 mL/min
* Patients have good compliance to treatment and follow-up of acceptance
* Forced expiratory volume in one second（FEV1） ≥ 1.5 litre or ≥ 75% of the reference value
* the functions of the heart, kidney, liver were basically normal, with no chemotherapy and radiotherapy contraindications

Exclusion Criteria:

* Patients with severely bowel function impaired or can not tolerate enteral nutrition
* Patients with serious gastrointestinal obstruction, be unable to take food by mouth and can not / do not want to a feeding tube inserted
* Patients have no risk of malnutrition
* Patients have severe malnutrition (weight loss \>10% or \<30 g/L, BMI\<18.5 kg/m2 or hemoglobin\<90 g/L before the treatment
* Patients who have severe vomiting, gastrointestinal bleeding, intestinal obstruction
* Patients can not tolerate chemotherapy and radiotherapy
* Patients who have distant metastasis
* The primary tumor or lymph node already received surgical treatment (except for biopsy);
* Patient who received radiotherapy for primary tumor or lymph node;
* Patient who received chemotherapy or immunotherapy;
* Patient who suffered from other malignant tumor;
* Patient who have taken other drug test within 1 month;
* Pregnant woman or Lactating Women and Women in productive age who refuse to take contraception in observation period;
* Subject with a severe allergic history or idiosyncratic;
* Subject with severe pulmonary and cardiopathic disease history;
* Refuse or incapable to sign the informed consent form of participating this trial;
* Drug abuse or alcohol addicted;
* Subject with a Personality or psychiatric diseases, people with no legal capacity or people with limited capacity for civil conduct;