Malignant Colon Neoplasm — Genomics · CancerIndex

Malignant Colon Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

6 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Colon Adenocarcinoma TCGA-COADTCGA

461 cases with simple somatic mutation data · 461 cases total · Data Release 46.0 · mapped to Colon Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	PTPRT	Ssm	348	461	75.5%	gdc
1	ZNF831	Ssm	348	461	75.5%	gdc
3	DIDO1	Ssm	345	461	74.8%	gdc
4	KCNB1	Ssm	343	461	74.4%	gdc
5	APC	Ssm	341	461	74%	gdc
6	LAMA5	Ssm	340	461	73.8%	gdc
7	CHD6	Ssm	339	461	73.5%	gdc
8	ZMYND8	Ssm

Data updated 23 days agoSource updated Data Release 46.0

Colon Adenocarcinoma (CaseCCC, PNAS 2015) coad_caseccc_2015CaseCCC

29 cases with simple somatic mutation data · 29 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm

Colon Adenocarcinoma (CPTAC GDC, 2025) coad_cptac_gdcCPTAC GDC

104 cases with simple somatic mutation data · 109 cases total · 2026-01-14 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	79	104

Colon Adenocarcinoma (TCGA GDC, 2025) coad_tcga_gdcTCGA GDC

429 cases with simple somatic mutation data · 463 cases total · 2026-01-19 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	308	429

Colon Cancer (CPTAC-2 Prospective, Cell 2019) coad_cptac_2019CPTAC-2 Prospective

106 cases with simple somatic mutation data · 110 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC

Colon Cancer (Sidra-LUMC AC-ICAM, Nat Med 2023) coad_silu_2022Sidra-LUMC AC-ICAM

281 cases with simple somatic mutation data · 348 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.