Subtype
Malignant Anorectal Neoplasm
CI-CAN-00005864Explore in graph →
452 active trials1 approved drugs6 evidence items
- NCIt
- C215225
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Subtype
CI-CAN-00005864Explore in graph →
Clinical trials
1,783 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (174)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT06281405 | CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer(TORCH-iTNT) | recruiting | Phase 2 | 192 | Fudan UniversityOTHER | 1 | Apr 3, 2026 | clinicaltrials |
| NCT07509424 | Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecitabine in Locally Advanced HER2-expressing Rectal Cance | not yet recruiting | Phase 2 | 29 | Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyOTHER |
| 0 |
| Apr 3, 2026 |
| clinicaltrials |
| NCT07509632 | Predicting Pathological Complete Response in Rectal Cancer Using Machine Learning | active not recruiting | — | 320 | Peking University People's HospitalOTHER | 1 | Apr 3, 2026 | clinicaltrials |
| NCT05108428 | Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma | active not recruiting | Early Phase 1 | 20 | H. Lee Moffitt Cancer Center and Research InstituteOTHER | 1 | Apr 1, 2026 | clinicaltrials |
| NCT05515796 | Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors | completed | Phase 2 | 189 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical UniversityOTHER | 1 | Apr 1, 2026 | clinicaltrials |
| NCT07505472 | Efficacy and Safety Comparison of Short-course Radiotherapy Followed by CapeOX Chemotherapy Plus Toripalimab With or Without Concurrent Surufatinib in Neoadjuvant Therapy for Mid-to-low Localized Rectal Cancer of High-risk Criteria(STARS-RC10) | recruiting | Phase 2 / Phase 3 | 212 | The First Hospital of Jilin UniversityOTHER | 1 | Apr 1, 2026 | clinicaltrials |
| NCT02437656 | Combination of Metformin to Neoadjuvant Radiochemotherapy in the Treatment of Locally Advanced Rectal Cancer.(METCAP) | completed | Phase 2 | 60 | Centre Oscar LambretOTHER | 1 | Mar 31, 2026 | clinicaltrials |
| NCT04963283 | Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer | active not recruiting | Phase 2 | 48 | University of Colorado, DenverOTHER | 1 | Mar 31, 2026 | clinicaltrials |
| NCT04703101 | Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer | recruiting | Phase 1 | 25 | Jonsson Comprehensive Cancer CenterOTHER | 1 | Mar 30, 2026 | clinicaltrials |
| NCT04234113 | Study of Nanrilkefusp Alfa Alone and With Pembrolizumab in Adult Patients With Advanced/Metastatic Solid Tumors | terminated | Phase 1 | 115 | SOTIO Biotech AGINDUSTRY | 4 | Mar 27, 2026 | clinicaltrials |
| NCT07494201 | MIMICC Study in Patients With Colorectal Cancer(MIMICC) | recruiting | N/A | 2,500 | Fondazione del Piemonte per l'OncologiaOTHER | 1 | Mar 27, 2026 | clinicaltrials |
| NCT06698289 | Preoperative Sarcopenia and Surgical Outcomes in Colorectal Cancer Patients | completed | — | 70 | Mersin UniversityOTHER | 1 | Mar 25, 2026 | clinicaltrials |
| NCT07369531 | The Impact of Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis on Stoma-free Survival in Low Rectal Anal-preserving Surgery(FIAS) | recruiting | N/A | 520 | The First Hospital of Jilin UniversityOTHER | 1 | Mar 25, 2026 | clinicaltrials |
| NCT06006260 | Changes of Low Anterior Resection Syndrome and Balance Ability in Patients With Rectal Cancer. | completed | — | 107 | Chang Gung Memorial HospitalOTHER | 1 | Mar 20, 2026 | clinicaltrials |
| NCT06628674 | Developing and Testing the Effect of Online Interactive Videos in Improving Low Anterior Resection Syndrome. | recruiting | N/A | 110 | Chang Gung Memorial HospitalOTHER | 1 | Mar 20, 2026 | clinicaltrials |
| NCT03853733 | Hypofractionated Palliative Radiotherapy in Patients With Advanced Non-operable Rectal Cancer | recruiting | — | 50 | Consorci Sanitari de TerrassaOTHER | 1 | Mar 19, 2026 | clinicaltrials |
| NCT07483060 | Next Generation STAR-TREC (NG-ST) - Organ Preservation in Early Rectal Cancer(NG-ST) | not yet recruiting | Phase 4 | 90 | Vastra Gotaland RegionOTHER_GOV | 0 | Mar 19, 2026 | clinicaltrials |
| NCT05806931 | Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer(SCOTI) | recruiting | Phase 2 | 50 | Rutgers, The State University of New JerseyOTHER | 1 | Mar 18, 2026 | clinicaltrials |
| NCT06181201 | Association Between the Composition of the Intestinal Microbiota and Tumor Response in Locally Advanced Rectal Cancer(Neo-Flo-Rect) | terminated | — | 2 | Centre Oscar LambretOTHER | 1 | Mar 18, 2026 | clinicaltrials |
| NCT03292289 | Assessment of Symptoms and Consequences of Coloanal Continuity Reconstruction(QUALIPRO) | completed | N/A | 65 | Centre Oscar LambretOTHER | 1 | Mar 17, 2026 | clinicaltrials |
| NCT04808323 | MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer | recruiting | Phase 1 | 22 | Medical College of WisconsinOTHER | 1 | Mar 16, 2026 | clinicaltrials |
| NCT07472868 | Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer(MEND-IT II) | not yet recruiting | Phase 3 | 394 | J. W. A. BurgerOTHER | 1 | Mar 16, 2026 | clinicaltrials |
| NCT07474103 | SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARC | recruiting | N/A | 49 | Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyOTHER | 1 | Mar 16, 2026 | clinicaltrials |
| NCT07469306 | Short-Course RT Plus CAPOX and Tislelizumab vs Long-Course CRT Plus Tislelizumab for Locally Advanced Rectal Cancer | not yet recruiting | Phase 2 | 130 | Fujian Cancer HospitalOTHER_GOV | 1 | Mar 13, 2026 | clinicaltrials |
| NCT04668872 | Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation | recruiting | — | 80 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Mar 12, 2026 | clinicaltrials |
| NCT04094454 | Intrafractional Vaginal Dilation in Anal Cancer Patients Undergoing Pelvic Radiotherapy(DILANA) | recruiting | N/A | 60 | Juergen DebusOTHER | 1 | Mar 10, 2026 | clinicaltrials |
| NCT07458529 | Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal Cancer(NCRIT-PM9) | recruiting | Phase 2 | 50 | Seventh Medical Center of PLA General HospitalOTHER | 1 | Mar 10, 2026 | clinicaltrials |
| NCT06292975 | Exercise for Improving Radiotherapy Efficacy in Rectal Cancer | withdrawn | N/A | 0 | University of HullOTHER | 1 | Mar 6, 2026 | clinicaltrials |
| NCT04075305 | The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study(MOMENTUM) | recruiting | — | 8,000 | UMC UtrechtOTHER | 9 | Mar 5, 2026 | clinicaltrials |
| NCT05731726 | Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer | recruiting | Phase 2 | 50 | Zhejiang UniversityOTHER | 1 | Mar 5, 2026 | clinicaltrials |
| NCT06952101 | A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity(INTERPRETE) | recruiting | N/A | 200 | Fondazione del Piemonte per l'OncologiaOTHER | 1 | Mar 5, 2026 | clinicaltrials |
| NCT07453173 | ONCO-RET: Supervised Resistance Training During Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer(ONCO-RET) | not yet recruiting | N/A | 15 | Fundacion Arturo Lopez PerezOTHER | 1 | Mar 5, 2026 | clinicaltrials |
| NCT04857528 | Detecting HPV DNA in Anal and Cervical Cancers | recruiting | — | 20 | University of ChicagoOTHER | 1 | Mar 4, 2026 | clinicaltrials |
| NCT06608537 | A Clinical Study Based on FAPI-PET/CT Technology to Predict Pathological Complete Response After Neoadjuvant Chemoradiotherapy for MSS Rectal Cancer | completed | Phase 2 | 52 | Sun Yat-sen UniversityOTHER | 1 | Mar 4, 2026 | clinicaltrials |
| NCT04215731 | Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer(FOBEAR) | recruiting | Phase 3 | 582 | Yanhong DengOTHER | 1 | Mar 3, 2026 | clinicaltrials |
| NCT02738359 | Efficacy of Colonoscopy, Colon Capsule and Fecal Immunological Test for Colorectal Cancer Screening(FAMCAP) | completed | — | 84 | Hôpital Edouard HerriotOTHER | 1 | Feb 27, 2026 | clinicaltrials |
| NCT04928807 | Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy and Camrelizumab in Locally Advanced Rectal Cancer (UNION) | active not recruiting | Phase 3 | 231 | Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyOTHER | 1 | Feb 27, 2026 | clinicaltrials |
| NCT07223567 | A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing pMMR/MSS Localized Rectal Cancer | withdrawn | Phase 2 | 0 | M.D. Anderson Cancer CenterOTHER | 0 | Feb 25, 2026 | clinicaltrials |
| NCT06625515 | First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers | terminated | Phase 1 | 17 | Accent TherapeuticsINDUSTRY | 1 | Feb 24, 2026 | clinicaltrials |
| NCT07427901 | Quality Of Life In Colorectal Cancer Survivors | recruiting | N/A | 368 | Institute of Oncology LjubljanaOTHER | 1 | Feb 23, 2026 | clinicaltrials |
| NCT07428239 | Pilot Study of Individualized Comprehensive Rehabilitation in Patients With Colorectal Cancer | completed | N/A | 150 | Institute of Oncology LjubljanaOTHER | 1 | Feb 23, 2026 | clinicaltrials |
| NCT04907643 | Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes | recruiting | N/A | 360 | Cedars-Sinai Medical CenterOTHER | 1 | Feb 20, 2026 | clinicaltrials |
| NCT01858025 | Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma | completed | Early Phase 1 | 25 | Massachusetts General HospitalOTHER | 1 | Feb 18, 2026 | clinicaltrials |
| NCT07410767 | Advanced Endoscopic Resections for Rectal Neoplasms | not yet recruiting | — | 300 | Jagiellonian UniversityOTHER | 1 | Feb 18, 2026 | clinicaltrials |
| NCT07337876 | Organ Preservation in Rectal Cancer by Dose Escalated MR Guided Adaptive Radiotherapy(MARS) | recruiting | Phase 2 | 100 | University Hospital TuebingenOTHER | 1 | Feb 17, 2026 | clinicaltrials |
| NCT07407465 | Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.(CHIMERA) | recruiting | Phase 2 | 42 | Gruppo Oncologico del Nord-OvestOTHER | 4 | Feb 17, 2026 | clinicaltrials |
| NCT04339374 | Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer | recruiting | N/A | 90 | Washington University School of MedicineOTHER | 1 | Feb 12, 2026 | clinicaltrials |
| NCT05673772 | Preoperative Sequential Short-course Radiation Therapy and FOLFOX for Locally Advanced Rectal Cancer(SOLAR) | active not recruiting | Phase 2 | 364 | Kyungpook National University HospitalOTHER | 1 | Feb 12, 2026 | clinicaltrials |
| NCT06670495 | HPV Genotype Attribution and Disease Burden of Anal Cancer in China | recruiting | — | 300 | Fudan UniversityOTHER | 1 | Feb 12, 2026 | clinicaltrials |
| NCT03516708 | Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer | recruiting | Phase 1 / Phase 2 | 49 | Washington University School of MedicineOTHER | 1 | Feb 11, 2026 | clinicaltrials |
Data updated 23 days agoSource updated Apr 3, 2026source: clinicaltrials