Lung Large Cell Carcinoma — Variants & evidence

Lung Large Cell Carcinoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ALK F1174L + ALK Fusion1
Crizotinib	Predictive	D	Supports Resistance	2	submitted	EID4041 In an in vitro study, a FL5.12 cell line expressing NPM1-ALK (a known sensitizing alteration to crizotinib) and an ALK F1174L co-mutation, demonstrated resistance to crizotinib treatment (IC50: 347.63… (full text at CIViC) PMID 27009859 · Amin et al., 2016 · Open in CIViC	civic
ALK R1192P1
Crizotinib	Predictive	D	Supports Resistance	—	submitted	EID4795 In an in vitro study, a FL5.12 cell line expressing NPM1-ALK (a known sensitizing alteration to crizotinib) and an ALK R1192P co-mutation, demonstrated resistance to crizotinib treatment (IC50: 421.5 … (full text at CIViC) PMID 27009859 · Amin et al., 2016 · Open in CIViC	civic
ALK I1171S + ALK Fusion1
Crizotinib	Predictive	D	Supports Resistance	2	submitted	EID4794 In an in vitro study, a FL5.12 cell line expressing NPM1-ALK or EML4-ALK (known sensitizing alterations to crizotinib) and an ALK I1171S co-mutation, demonstrated resistance to crizotinib treatment (I… (full text at CIViC) PMID 27009859 · Amin et al., 2016 · Open in CIViC	civic
ALK T1151M + ALK Fusion1
Crizotinib	Predictive	D	Supports Resistance	2	submitted	EID4431 In an in vitro study, a FL5.12 cell line expressing NPM1-ALK (a known sensitizing alteration to crizotinib) and an ALK T1151M co-mutation, demonstrated resistance to crizotinib treatment (IC50: 346.65… (full text at CIViC) PMID 27009859 · Amin et al., 2016 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.