Subtype
Large Intestinal Neoplasm
CI-CAN-00001062Explore in graph →
Non-malignant1,847 active trials21 approved drugs383 evidence items
- NCIt
- C215201
Loading cancer entity…
Loading cancer entity…
Subtype
CI-CAN-00001062Explore in graph →
Clinical trials
8,849 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT06856837 | - IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases | recruiting | Phase 2 | 140 | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus NordwestOTHER | 2 | Dec 12, 2025 | clinicaltrials |
| NCT05639413 | A Clinical-biological Prospective Cohort of Patients With BRAFV600E-mutated Metastatic Colorectal Cancer(COBRAF) | recruiting | N/A | 400 | UNICANCEROTHER |
| 1 |
| Dec 10, 2025 |
| clinicaltrials |
| NCT05993923 | Impact of a Multidisciplinary Approach in the Perioperative Geriatrics Unit on Functional Status of Patients Aged 70 and Over Operated on for Colorectal Cancer(DIGER) | recruiting | N/A | 90 | Centre Hospitalier Universitaire de NīmesOTHER | 1 | Dec 10, 2025 | clinicaltrials |
| NCT06245356 | Safety of Trifluridine/Tipiracil in Patients With Dihydropyrimidine Dehydrogenase Deficiency Diagnosed With Metastatic Colorectal or Gastroesophageal Cancer(TRIFLUOX-DP) | recruiting | Phase 2 | 73 | UNICANCEROTHER | 1 | Dec 10, 2025 | clinicaltrials |
| NCT06380101 | Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (LARC)(NEAAR-LARC) | recruiting | N/A | 30 | University of South FloridaOTHER | 1 | Dec 10, 2025 | clinicaltrials |
| NCT07221058 | Adaptive Radiation Boost for Rectal Cancer(ARBOR) | recruiting | Phase 1 | 37 | Fox Chase Cancer CenterOTHER | 1 | Dec 9, 2025 | clinicaltrials |
| NCT07272772 | Colon Cancer Diagnosis With FAPI-PET Imaging | recruiting | Phase 2 / Phase 3 | 100 | Turku University HospitalOTHER_GOV | 1 | Dec 9, 2025 | clinicaltrials |
| NCT06733038 | FOLFOXIRI Plus Bevacizumab With or Without Atezolizumab as 1st Line Treatment of pMMR and IS IC-High Metastatic Colorectal Cancer Patients.(AtezoTRIBE2) | recruiting | Phase 3 | 238 | Gruppo Oncologico del Nord-OvestOTHER | 1 | Dec 8, 2025 | clinicaltrials |
| NCT07269249 | Real-world Efficacy and Safety of Neoadjuvant Dostarlimab in Patients With dMMR/MSI-H Locally Advanced Rectal Cancer(RW-NEDOS) | recruiting | — | 50 | National Cancer Institute, NaplesOTHER | 1 | Dec 8, 2025 | clinicaltrials |
| NCT06731894 | Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors | recruiting | Phase 2 | 120 | City of Hope Medical CenterOTHER | 1 | Dec 5, 2025 | clinicaltrials |
| NCT06236633 | Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle Rectum(AMIREMBOL_2) | recruiting | N/A | 30 | Centre Hospitalier Universitaire de NīmesOTHER | 1 | Dec 4, 2025 | clinicaltrials |
| NCT06522256 | Identification of Molecular Signatures of High-risk Oncogenic HPV and Study of Their Associations With the Presence of High-grade Lesions and/or Anal Cancer 10 Years After Inclusion in the ANRS IPERGAY Trial(HPVsign) | recruiting | N/A | 100 | ANRS, Emerging Infectious DiseasesOTHER_GOV | 1 | Dec 4, 2025 | clinicaltrials |
| NCT07262840 | Health Behavior Change in High-Risk Colorectal Cancer Individuals | recruiting | N/A | 80 | China Medical University, ChinaOTHER | 1 | Dec 4, 2025 | clinicaltrials |
| NCT07263178 | A Study of Second- and Later-line Palliative Chemotherapy in Patients With Metastatic Colorectal Cancer. | recruiting | — | 1,000 | Boryung Pharmaceutical Co., LtdINDUSTRY | 1 | Dec 4, 2025 | clinicaltrials |
| NCT07264556 | Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery | recruiting | N/A | 90 | Fudan UniversityOTHER | 1 | Dec 4, 2025 | clinicaltrials |
| NCT05642819 | REVOLUTION Surgery (REVOLUTION Surgery) | recruiting | — | 200 | University of EdinburghOTHER | 1 | Dec 2, 2025 | clinicaltrials |
| NCT05786716 | DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations(DETERMINE) | recruiting | Phase 2 / Phase 3 | 30 | Cancer Research UKOTHER | 1 | Dec 2, 2025 | clinicaltrials |
| NCT07257653 | The Safety and Efficacy of Cetuximab Beta Plus Fruquintinib With or Without Immune Checkpoint Inhibitorrs in First-line Treatment of RAS/BRAF Wild Type Unresectable Metastatic Colorectal Cancer(concept) | recruiting | Phase 2 | 70 | Zhejiang UniversityOTHER | 1 | Dec 2, 2025 | clinicaltrials |
| NCT07259590 | A Study of GFH375 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors Harboring KRAS G12D Mutation | recruiting | Phase 1 / Phase 2 | 126 | Genfleet Therapeutics (Shanghai) Inc.INDUSTRY | 1 | Dec 2, 2025 | clinicaltrials |
| NCT06154538 | Immune Checkpoint Inhibitors + Chemotherapy Versus Chemotherapy in the Neoadjuvant Treatment of Locally Advanced Colorectal Cancer | recruiting | Phase 2 | 170 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 1 | Nov 28, 2025 | clinicaltrials |
| NCT06904677 | Using 4D Urinary Proteomics to Predict and Evaluate Treatment Response in Colorectal Cancer | recruiting | — | 400 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 1 | Nov 28, 2025 | clinicaltrials |
| NCT06193356 | Detection of Endoscopic Resection Scars and Delineation of Recurrence is Trainable(SCAR) | recruiting | N/A | 141 | University Hospital, GhentOTHER | 1 | Nov 25, 2025 | clinicaltrials |
| NCT07249333 | Perioperative Complications After Neoadjuvant Radiotherapy for Colorectal Cancer | recruiting | — | 80 | Oncology Institute of VojvodinaOTHER_GOV | 1 | Nov 25, 2025 | clinicaltrials |
| NCT05051046 | Colorectal Cancer Screnning Colonoscopy Under Hypnosis(CODEPICCH) | recruiting | N/A | 600 | University Hospital, ToursOTHER | 1 | Nov 24, 2025 | clinicaltrials |
| NCT05768178 | DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.(DETERMINE) | recruiting | Phase 2 / Phase 3 | 30 | Cancer Research UKOTHER | 1 | Nov 24, 2025 | clinicaltrials |
| NCT05770102 | DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition(DETERMINE) | recruiting | Phase 2 / Phase 3 | 30 | Cancer Research UKOTHER | 1 | Nov 24, 2025 | clinicaltrials |
| NCT07244705 | A Study of ABT-301 Plus Tislelizumab With Bevacizumab in pMMR/Non-MSI-H Locally Advanced or mCRC | recruiting | Phase 1 / Phase 2 | 66 | Anbogen Therapeutics, Inc.INDUSTRY | 2 | Nov 24, 2025 | clinicaltrials |
| NCT07069556 | ColoSense Post-Approval Study | recruiting | — | 12,500 | Geneoscopy, Inc.INDUSTRY | 1 | Nov 21, 2025 | clinicaltrials |
| NCT03926338 | Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer(PICC) | recruiting | Phase 2 | 270 | Sun Yat-sen UniversityOTHER | 1 | Nov 20, 2025 | clinicaltrials |
| NCT06560671 | Compare the Patient Satisfaction and Effectiveness After Novel Application-based or Conventional Health Education of Bowel Preparation for Colonoscopy | recruiting | N/A | 252 | National Taiwan University HospitalOTHER | 1 | Nov 20, 2025 | clinicaltrials |
| NCT06652672 | Sentinel Node and Organ-sparing Surgery in Stage I Colon Carcinoma(SENTRY) | recruiting | N/A | 341 | Meander Medical CenterOTHER | 1 | Nov 20, 2025 | clinicaltrials |
| NCT06940947 | Endoscopic Therapy Or Surgery for Early Colon Cancer(ETHOS) | recruiting | Phase 3 | 434 | Norwegian Department of Health and Social AffairsOTHER_GOV | 1 | Nov 20, 2025 | clinicaltrials |
| NCT07237438 | TIVA Versus Balanced Anesthesia on Muscle Mass in CRC Surgery(TIVABAL-CRC) | recruiting | N/A | 40 | Grigore T. Popa University of Medicine and PharmacyOTHER | 1 | Nov 19, 2025 | clinicaltrials |
| NCT05748145 | Metronidazole as Preoperative Therapy in CRC / FusoMetro-001 | recruiting | Phase 2 | 40 | Oncology Institute of Southern SwitzerlandOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT06222645 | PPG vs. ICG in Gastrointestinal Resections | recruiting | N/A | 200 | Saint Petersburg State University, RussiaOTHER | 2 | Nov 18, 2025 | clinicaltrials |
| NCT06272461 | Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery | recruiting | N/A | 50 | University Tunis El ManarOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT06919068 | Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria(AB-care) | recruiting | — | 100 | Odense University HospitalOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT07106892 | Phase II, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of HLX43 (an Anti-PD-L1 ADC) in Subjects With Advanced Colorectal Cancer | recruiting | Phase 2 | 60 | Shanghai Henlius BiotechINDUSTRY | 1 | Nov 17, 2025 | clinicaltrials |
| NCT06376565 | Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps | recruiting | N/A | 1,680 | Jonsson Comprehensive Cancer CenterOTHER | 1 | Nov 14, 2025 | clinicaltrials |
| NCT07158164 | DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment | recruiting | Phase 4 | 100 | Rutgers, The State University of New JerseyOTHER | 1 | Nov 13, 2025 | clinicaltrials |
| NCT04792684 | Collection of Samples USOPTIVAL Study | recruiting | — | 1,300 | Universal DiagnosticsINDUSTRY | 1 | Nov 10, 2025 | clinicaltrials |
| NCT06059963 | A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation | recruiting | — | 12,000 | Universal DiagnosticsINDUSTRY | 1 | Nov 10, 2025 | clinicaltrials |
| NCT07130903 | Amplitude-Modulated Radiofrequency Electromagnetic Fields (AM RF EMF) in Combination With Fruquintinib in Refractory Metastatic Colorectal Cancer | recruiting | Phase 2 | 102 | Barbara Ann Karmanos Cancer InstituteOTHER | 1 | Nov 10, 2025 | clinicaltrials |
| NCT03452774 | SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry | recruiting | — | 50,000 | Massive Bio, Inc.INDUSTRY | 2 | Oct 28, 2025 | clinicaltrials |
| NCT07167446 | Neuroprotective Potential of Cannabidiol (CBD) in Preventing Oxaliplatin (Ox)-Induced Neuropathy | recruiting | Early Phase 1 | 30 | Fox Chase Cancer CenterOTHER | 1 | Oct 22, 2025 | clinicaltrials |
| NCT03551951 | Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow | recruiting | — | 320 | University of Missouri-ColumbiaOTHER | 1 | Oct 8, 2025 | clinicaltrials |
| NCT06960291 | Sustainable Implementation of the EXCEL Exercise Oncology Program Across Canada(EXCEL) | recruiting | N/A | 740 | University of CalgaryOTHER | 1 | Oct 7, 2025 | clinicaltrials |
| NCT06433349 | A Multi-center Investigation of Family Health. | recruiting | — | 240 | Odense University HospitalOTHER | 1 | Oct 6, 2025 | clinicaltrials |
| NCT04780256 | Endoscopic Resection of Gastrointestinal Neoplasms | recruiting | — | 2,000 | Azienda USL Reggio Emilia - IRCCSOTHER_GOV | 1 | Oct 3, 2025 | clinicaltrials |
Data updated 23 days agoSource updated Dec 12, 2025source: clinicaltrials