Clinical trial · Interventional
Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal (Colon or Rectal) Cancer | Childhood Colorectal Carcinoma | ALIAS | 0.90 |
| Inflammation | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ketamine Injectable Solution | Drug | — | UNRESOLVED |
| Lidocaine IV | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- IV-Lido
- description
- Intravenous Lidocaine dose loading than continuous infusion
- interventionNames
- Drug: Lidocaine IV
- type
- ACTIVE_COMPARATOR
- label
- IV-Keta
- description
- Intravenous Ketamine dose loading than continuous infusion
- interventionNames
- Drug: Ketamine Injectable Solution
Primary outcomes (1)
- measure
- The variation of Interleukin-6 levels
- timeFrame
- 24 hours after surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
INCLUSION CRITERIA: * Patients aged 18 or older. * American society of anesthesiologists' (ASA) physical status of I-III. * Elective open colorectal surgery. NON INCLUSION CRITERIA: * Patients with contraindications to lidocaine or ketamine. * Corticosteroid therapy within the last 6 months. * History of immunosuppressive therapy. * History of surgery in the last 3 months. * Personal medical history of inflammatory bowel disease. * Personal medical history of cardiac arrythmias or conduction disorders. * Alcohol or drug abuse. * Chronic use of opioids or benzodiazepines. EXCLUSION CRITERIA: * Severe intraoperative complications. * Duration of surgery longer than 5 hours.
References
Publications (0)
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