Clinical trial · Observational
Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria
Colonic Capsule Endoscopy for Screening of Neoplasms in Patients With Anaerobic Bacteremia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria. The main question it aims to answer is: • How prevalent is cancer and precancerous tumors in the large intestines and rectum in patients with anaerobic bacteremia? Participants will be offered an examination using colon capsule endoscopy 4-8 weeks after discharge.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anaerobic Infection | — | UNRESOLVED | — |
| Bacteriaemia | — | UNRESOLVED | — |
| Blood Stream Infection | — | UNRESOLVED | — |
| Colorectal Cancer and Pre-cancer Polyps | — | UNRESOLVED | — |
| Colorectal Cancer (CRC) | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Colon capsule endoscopy | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Colorectal cancer and precancerous tumors
- timeFrame
- 4-8 weeks after hospitalization with anaerobic gut-associated bacteria
- description
- Prevalence of colorectal cancer and precancerous tumors using colon capsule endoscopy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Older than 18 years * Blood culture with growth of one or more of the following bacterial genera Bacteroides, Clostridium, Filifactor, Fusobacterium, Gemella, Granulicatella, Parvimonas, Peptostreptococcus, Prevotella, Solobacterium, Peptoniphilus, Ruminococcus, Finegoldia and Streptococcus. * Able to provide oral and written informed consent * Able to read and speak Danish Exclusion Criteria: * Prior colorectal cancer diagnosis * History of stenosis of the gastrointestinal tract * Previous treatment of inflammatory bowel disease * Previous major surgery of the gastrointesinal tract (e.g. gastric bypass) * Colostomy * Pacemaker/ICD * Pregnancy or breastfeeding * Allergies to the bowel preparation regimen * Severe kidney disease * Focus of infection in skin and soft tissue or outside the truncus (e.g. decubitus, diabetic foot ulcer) * Tumor in the colon or rectum at diagnostic imaging * Transfer to other hospital outside the region
References
Publications (3)
- BACKGROUNDLaupland KB, Edwards F, Furuya-Kanamori L, Paterson DL, Harris PNA. Bloodstream Infection and Colorectal Cancer Risk in Queensland Australia, 2000-2019. Am J Med. 2023 Sep;136(9):896-901. doi: 10.1016/j.amjmed.2023.05.003. Epub 2023 May 23. PMID 37230400
- BACKGROUNDJustesen US, Nielsen SL, Jensen TG, Dessau RB, Moller JK, Coia JE, Andersen SL, Pedersen C, Gradel KO. Bacteremia With Anaerobic Bacteria and Association With Colorectal Cancer: A Population-based Cohort Study. Clin Infect Dis. 2022 Nov 14;75(10):1747-1753. doi: 10.1093/cid/ciac259. PMID 35380653
- BACKGROUNDJustesen US, Ellebaek MB, Qvist N, Iachina M, Frimodt-Moller N, Soes LM, Skovgaard S, Lemming L, Samulioniene J, Andersen SL, Dessau RB, Moller JK, Coia JE, Gradel KO. Colorectal cancer and association with anaerobic bacteraemia: A Danish nationwide population-based cohort study. J Infect. 2024 Aug;89(2):106212. doi: 10.1016/j.jinf.2024.106212. Epub 2024 Jul 2. PMID 38960102