Invasive Breast Carcinoma

A 6-year-old female had invasive breast adenocarcinoma with the histopathologic features of a secretory breast carcinoma (SBC). FISH and RT-PCR on frozen tumor tissue found ETV6::NTRK3 fusion. 11 of … (full text at CIViC)

PMID 12450792 · Tognon et al., 2002 · Open in CIViC

In developing a FISH assay to detect ETV6::NTRK3 fusions, the authors found 3 of 4 secretary breast carcinomas were positive for the fusion. In a subsequent analysis of an invasive breast carcinoma t… (full text at CIViC)

PMID 15101049 · Makretsov et al., 2004 · Open in CIViC

12 of 13 (92%) secretory breast carcinomas were found to have ETV6::NTRK3 fusions by RT-PCR and/or FISH whereas other infiltrating ductal carcinomas were negative for the fusion.

PMID 12450792 · Tognon et al., 2002 · Open in CIViC

9 of 9 breast secretory carcinomas were found to have ETV6:NTRK3 fusions, a basal-like phenotype, and no additional pathogenic aberrations in genes commonly mutated in breast cancer.

PMID 28548128 · Krings et al., 2017 · Open in CIViC

A 6-year-old female was diagnosed with secretory breast carcinoma (SBC), a rare invasive breast adenocarcinoma. Analysis of the tumor revealed a genetic driver: an ETV6::NTRK3 gene fusion. This fusion… (full text at CIViC)

PMID 12450792 · Tognon et al., 2002 · Open in CIViC

Shukla et al report on a remarkable case study of a 14 year old pediatric patient with refractory secretory breast carcinoma first presenting as a fibroadenoma at 8 yo. Over the next years, she experi… (full text at CIViC)

PMID 29623306 · Shukla et al., 2017 · Open in CIViC

MMP2 serum levels were assessed (ELISA) at baseline (b) and before surgery in 45 available samples from patients with inflammatory breast cancer treated with bevacizumab-based neoadjuvant therapy. Hig… (full text at CIViC)

PMID 26921265 · Tabouret et al., 2016 · Open in CIViC

MMP9 serum levels were assessed (ELISA) at baseline (b) and before surgery in 45 available samples from patients with inflammatory breast cancer treated with bevacizumab-based neoadjuvant therapy. Low… (full text at CIViC)

PMID 26921265 · Tabouret et al., 2016 · Open in CIViC

In a retrospective analysis of 32 Western Chinese female patients with invasive ductal breast cancer, PIK3CA H1047L (n=1) or H1047R (n=8) was associated with worse survival and increased incidence of … (full text at CIViC)

PMID 28269754 · Cheng et al., 2017 · Open in CIViC