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Intracranial Neoplasm — Research · CancerIndex

Cancers
Neoplasm
Neoplasm by Site
Nervous System Neoplasm
Central Nervous System Neoplasm
Intracranial Neoplasm

Subtype

Intracranial Neoplasm

CI-CAN-00001030Explore in graph →

Non-malignant521 active trials34 evidence items

NCIt: C4953

Overview
Statistics
Survival
Genomics7
Variants & evidence34
Drugs5
Trials2177
Research
Rankings
Sources & provenance

Research activity

PubMed record counts

Each count is the number of PubMed records returned by the exact query shown, at the time it was run. Counts are research-activity signals, not quality measures.

Data not yet available

No PubMed query has been run for this entity. Counts require a MeSH-anchored query built from the entity's terminology mappings; the query string is stored with each count so it can be reproduced.

What CancerIndex knows

Trials tab
Methodology: publication counts

Literature

Linked publications (33)

Publications linked to this entity or its descendants, newest first, 25 per page. Link method and validation status are shown; 'candidate' links have not been reviewed.

pubmedProvenance

Source: PubMed (NLM)
Dataset: PubMed E-utilities
Retrieved: Sep 8, 2026
Layer: normalized (units and labels harmonized; values unchanged)

PublishedShowing 1–25 of 33 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
· Acta Neuropathol · 2016 · PMID 27157931 · validated civic_curation pubmed
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
· Lancet Oncol · 2017 · PMID 28545823 · validated civic_curation pubmed
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
· Cancer Cell · 2014 · PMID 24651015 · validated civic_curation pubmed
Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.
· Cell Cycle · 2006 · PMID 17172831 · validated civic_curation pubmed
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.
· Cell · 2016 · PMID 26919435 · validated civic_curation pubmed
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
· Cancer Cell · 2015 · PMID 25965575 · validated civic_curation pubmed
Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation.
· Acta Neuropathol Commun · 2021 · PMID 33536079 · validated

Showing 1–25 of 33 publications

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civic_curation

Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features.

· Brain Pathol · 2019 · PMID 30246434 · validated civic_curation pubmed

Supratentorial CNS-PNETs in children; a Swedish population-based study with molecular re-evaluation and long-term follow-up.

· Clin Epigenetics · 2023 · PMID 36895035 · validated civic_curation pubmed

Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme.

· Cancer Res · 2003 · PMID 14583498 · validated civic_curation pubmed

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.

· Nat Genet · 2012 · PMID 22286216 · validated civic_curation pubmed

Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics.

· J Pathol · 2009 · PMID 19197950 · validated civic_curation pubmed

C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.

· Nature · 2014 · PMID 24553141 · validated civic_curation pubmed

A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma.

· Neurooncol Adv · 2023 · PMID 37287693 · validated civic_curation pubmed

Molecular grouping and outcomes of young children with newly diagnosed ependymoma treated on the multi-institutional SJYC07 trial.

· Neuro Oncol · 2019 · PMID 30976811 · validated civic_curation pubmed

Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway.

· Acta Neuropathol · 2014 · PMID 24562983 · validated civic_curation pubmed

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

· J Clin Oncol · 2015 · PMID 26169613 · validated civic_curation pubmed

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

· Science · 2009 · PMID 19726788 · validated civic_curation pubmed

Phase II Study of Erdafitinib in Patients With Tumors With Fibroblast Growth Factor Receptor Mutations or Fusions: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol K2.

· JCO Precis Oncol · 2024 · PMID 38603650 · validated civic_curation pubmed

Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.

· Acta Neuropathol Commun · 2021 · PMID 34389065 · validated civic_curation pubmed

NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls.

· Mod Pathol · 2020 · PMID 31375766 · validated civic_curation pubmed

Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): Molecular Profiling Confirms Frequent MAPK Pathway Activation.

· J Neuropathol Exp Neurol · 2021 · PMID 34363682 · validated civic_curation pubmed

Supratentorial ependymoma with YAP1:FAM118B fusion: A case report.

· Neuropathology · 2021 · PMID 33480048 · validated civic_curation pubmed

Entrectinib demonstrates prolonged efficacy in an adult case of radiation-refractory NTRK fusion glioblastoma.

· Neurooncol Adv · 2022 · PMID 35673607 · validated civic_curation pubmed

A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB.

· Cell Rep · 2018 · PMID 29949764 · validated civic_curation pubmed