Publication
NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (10)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 10
- cancerBrain Glioblastomacivic_curation1.00
- cancerColon Adenocarcinomacivic_curation1.00
- cancerGlioblastomacivic_curation1.00
- cancerLow Grade Gliomacivic_curation1.00
- cancerPoorly Differentiated Thyroid Gland Carcinomacivic_curation1.00
- geneNTRK2civic_curation1.00
- geneNTRK3civic_curation1.00
- variantNTRK2 Fusioncivic_curation1.00
- variantNTRK2 Fusioncivic_curation1.00
- variantNTRK3 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 31375766
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NTRK2 Fusion1 | ||||||||
| (oncogenic) | Brain GlioblastomaALIAS | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID10896From a retrospective review of 38,095 tumor samples from 33,997 patients that underwent fusion screening at Memorial Sloan Kettering Cancer Center, 87 tumors were found to be positive for an NTRK1, NT… (full text at CIViC) PMID 31375766 · Solomon et al., 2020 · Open in CIViC | civic |
| NTRK3 Fusion3 | ||||||||
| (oncogenic) | Colon Adenocarcinoma | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID10506From a retrospective review of 38,095 tumor samples from 33,997 patients using DNA sequencing (MSK-IMPACT) and RNA sequencing (MSK-Fusion panel) identified 87 tumors with NTRK1-3 fusions. Two cases of… (full text at CIViC) PMID 31375766 · Solomon et al., 2020 · Open in CIViC | civic |
| 〃 | GlioblastomaCURATED_BROADER | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID10507From a retrospective review of 38,095 tumor samples from 33,997 patients using DNA sequencing (MSK-IMPACT) and RNA sequencing (MSK-Fusion panel) identified 87 tumors with NTRK1-3 fusions. One case of… (full text at CIViC) PMID 31375766 · Solomon et al., 2020 · Open in CIViC | civic |
| 〃 | Poorly Differentiated Thyroid Gland CarcinomaALIAS | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID10508From a retrospective review of 38,095 tumor samples from 33,997 patients using DNA sequencing (MSK-IMPACT) and RNA sequencing (MSK-Fusion panel) identified 87 tumors with NTRK1-3 fusions. One case of … (full text at CIViC) PMID 31375766 · Solomon et al., 2020 · Open in CIViC | civic |
| NTRK2 Fusion1 | ||||||||
| (oncogenic) | Low Grade Glioma | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID11437From a retrospective review of 38,095 tumor samples from 33,997 patients that underwent fusion screening at Memorial Sloan Kettering Cancer Center, 87 tumors were found to be positive for an NTRK1, NT… (full text at CIViC) PMID 31375766 · Solomon et al., 2020 · Open in CIViC | civic |