Intestinal Neoplasm

As high expression of FOXF1 was associated with higher progression, poorer survival, and increased microvessel density in colorectal cancer (CRC) patients (p < 0.001), the in vitro effects of bevacizu… (full text at CIViC)

PMID 30253191 · Wang et al., 2018 · Open in CIViC

shRNA-mediated reduction of FPGS expression increased fluorouracil sensitivity in colorectal cancer cells, producing approximately threefold and sixfold decreases in IC50 in HCT-116 and HT-29 cells, r… (full text at CIViC)

PMID 21449674 · Muhale et al., 2011 · Open in CIViC

Reduced GGH expression by shRNA significantly sensitized HCT-116, HT-29, and SW620 colorectal cancer cells to fluorouracil. Across the DHFR/GGH experiments (note that these are summarized together in-… (full text at CIViC)

PMID 21449674 · Muhale et al., 2011 · Open in CIViC

In a retrospective study of 151 patients with sporadic colorectal cancer, 5-year survival rate was significantly higher in patients with International Union Against Cancer (UICC) stages I to II (mean … (full text at CIViC)

PMID 16033819 · Frey et al., 2005 · Open in CIViC

Patients with the GSTP1 I105V variant had greater response to FOLFOX-4 treatment, longer progression-free survival, and longer overall survival. 166 Chinese patients with metastatic colorectal carcino… (full text at CIViC)

PMID 19922504 · Chen et al., 2010 · Open in CIViC

HIF1A overexpression was assessed by IHC in 731 colorectal cancers from two prospective cohort studies. 142 (19%) tumors showed HIF1A overexpression. Overexpression of HIF1A was associated with higher… (full text at CIViC)

PMID 20363910 · Baba et al., 2010 · Open in CIViC

A patient with metastatic colorectal cancer was enrolled in a phase 2 clinical trial (NCT01174121). 24 cultures of tumor-infiltrating lymphocytes were expanded from 3 lung metastasis resections. After… (full text at CIViC)

PMID 27959684 · Tran et al., 2016 · Open in CIViC

In an in vitro study, DiFi colorectal cancer cell lines stably expressing HRAS G12V mutation demonstrated resistance to cetuximab treatment compared to DiFi cells expressing wild-type HRAS. Resistance… (full text at CIViC)

PMID 22797062 · Kasper et al., 2013 · Open in CIViC

In an in vitro study, Colo-320, SW48, and CaCO2 cell lines expressing HRAS G13D mutation were associated with resistance to cetuximab treatment, as compared to Colo-320, SW48, and CaCO2 cells expressi… (full text at CIViC)

PMID 26561417 · Boidot et al., 2016 · Open in CIViC

Case report of a patient with metastatic colorectal carcinoma and a novel HRAS G13D mutation showed resistance to treatment with panitumumab. In vitro models of HRAS G13D confirmed resistance mechanis… (full text at CIViC)

PMID 26561417 · Boidot et al., 2016 · Open in CIViC

Expression of GRP78 (HSPA5) in colorectal cancer patients (n=396, by IHC) showed improved benefit from adjuvant chemotherapy in stage III patients (52% vs. 28%; p = 0.026). In vitro, GRP78 inhibition … (full text at CIViC)

PMID 23456958 · Thornton et al., 2013 · Open in CIViC

329 consecutive patients with stage II–III colorectal tumors with MSI after surgical resection at tertiary medical centers were screened for HSP110 T(17) by PCR. Patients underwent adjuvant chemothera… (full text at CIViC)

PMID 24512910 · Collura et al., 2014 · Open in CIViC

Cell lines with IRS2 copy number gain had higher levels of ligand-stimulated activation of IGF-1R and AKT. IRS2 siRNA knockdown reduced IRS2 protein expression levels and decreased sensitivity to BMS-… (full text at CIViC)

PMID 25527633 · Huang et al., 2015 · Open in CIViC

This study finds JAK1 and JAK2 mutation as determinants of primary resistance to PD-1 blockade therapy. Baseline tumors from patients with melanoma and colon cancer who did not respond to PD-1 blockad… (full text at CIViC)

PMID 27903500 · Shin et al., 2017 · Open in CIViC

A 67-year-old female presents with recurrent metastatic colonic adenocarcinoma. Immunohistochemical and genetic workup showed overexpression of c-JUN and FOS, which presumably signals through the RAA… (full text at CIViC)

PMID 27022066 · Jones et al., 2016 · Open in CIViC

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G800D caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G800R caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G843D caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) L840F caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) R1022Q caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGF… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) R1032Q caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGF… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

R1032Q affects the gene's universal kinase catalytic motif. The authors found that injection of mice with COLO-320 cells that harbor this mutation resulted in tumor generation, indicating that this mu… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

Case Report of a 84-year-old woman with stage IVb CRC after progression under 5-fluorouracil and bevacizumab. NGS revealed a frameshift mutation in APC, a missense mutation in KRAS. Variants of uncert… (full text at CIViC)

PMID 27004155 · Loaiza-Bonilla et al., 2016 · Open in CIViC

The colon cancer cell line COLO-320 was transfected with VEGFR2 (KDR) S1100F mutation. When injected into immune deficient mice, these cells were capable of causing tumor formation reaching the establ… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) S925F caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

In a case study, a patient with anal melanoma harboring a 7 codon duplication in the juxtamambrane region (exon 11) of KIT showed marked response 4 months after imatinib treatment.

PMID 18421059 · Hodi et al., 2008 · Open in CIViC

In a retrospective TCGA cohort of microsatellite-instable colorectal adenocarcinoma (n = 43; KMT2D LOF = 16, WT = 27), KMT2D loss of function was associated with higher TMB (p < 0.001), higher neoanti… (full text at CIViC)

PMID 39578878 · Takemon et al., 2024 · Open in CIViC

In microsatellite-instable (MSI) colorectal carcinoma cell-line assays, KMT2D loss of function (LOF) stratified sensitivity to WRN perturbation. In DepMap viability data, WRN knockout was lethal in MS… (full text at CIViC)

PMID 39578878 · Takemon et al., 2024 · Open in CIViC

FFPE tumor tissue from 1506 colorectal adenocarcinoma patients was analyzed at codons 12, 13, 61 and 146 by PCR. 672 KRAS mutations were found in 670 patients, and from these, two were inframe inserti… (full text at CIViC)

PMID 24642870 · Tong et al., 2014 · Open in CIViC

A study of 419 patients with liver metastases of colorectal cancer identified 12 with A146 mutations. Compared to KRAS G12 tumors, patients with A146 positive tumors exhibited higher ctDNA levels. Pat… (full text at CIViC)

PMID 34820593 · van 't Erve et al., 2021 · Open in CIViC

This was a retrospective study of 605 patients with metastatic, chemotherapy refractory colorectal cancer treated with cetuximab + chemotherapy. Patients harboring KRAS codon 146 mutant tumors (n=11) … (full text at CIViC)

PMID 20619739 · De Roock et al., 2010 · Open in CIViC

In a systematic analysis of KRAS mutations across 2,280 KRAS-mutant colorectal cancer samples from three large clinical sequencing cohorts (DFCI, TCGA, MSKCC), KRAS A146P was confirmed as one of three… (full text at CIViC)

PMID 41299036 · Navarro-Jiménez et al., 2025 · Open in CIViC

Edkins et al. identified KRAS c.436G>C (p.A146P) in one primary colorectal cancer, PD1978a, during sequencing of two independent colorectal cancer cohorts. Normal DNA from the same individuals was ana… (full text at CIViC)

PMID 16969076 · Edkins et al., 2006 · Open in CIViC

The variant was found in 6 of 220 primary colorectal cancer patients. Found in 2 Colorectal Cancer cell lines: HCC2998 and LS1034 Found in 1 AML cell line: ML-2 Mutations of this residue presumably al… (full text at CIViC)

PMID 16969076 · Edkins et al., 2006 · Open in CIViC

In irinotecan-resistant metastatic colorectal cancer patients who had been treated with cetuximab and irinotecan, KRAS mutations in codon 61 or 146 were associated with shorter progression-free surviv… (full text at CIViC)

PMID 19603018 · Loupakis et al., 2009 · Open in CIViC